Childhood socio-economic disadvantages versus adverse care experiences: Mediation and moderation impacts on late-life depressive symptoms.

Autor:	Huang YY; School of Public Health, Sun Yat-sen University, Guangzhou, China.; Greater Bay Area Public Health Research Collaboration, China., Zhang WS; Guangzhou Twelfth People's Hospital, Guangzhou, China.; Greater Bay Area Public Health Research Collaboration, China., Jiang CQ; Guangzhou Twelfth People's Hospital, Guangzhou, China.; Greater Bay Area Public Health Research Collaboration, China., Zhu F; Guangzhou Twelfth People's Hospital, Guangzhou, China., Jin YL; Guangzhou Twelfth People's Hospital, Guangzhou, China., Au Yeung SL; School of Public Health, The University of Hong Kong, Hong Kong, China.; Greater Bay Area Public Health Research Collaboration, China., Wang J; School of Public Health, Sun Yat-sen University, Guangzhou, China.; Greater Bay Area Public Health Research Collaboration, China., Cheng KK; Institute of Applied Health Research, University of Birmingham, Birmingham, UK., Lam TH; Guangzhou Twelfth People's Hospital, Guangzhou, China.; School of Public Health, The University of Hong Kong, Hong Kong, China.; Greater Bay Area Public Health Research Collaboration, China., Xu L; School of Public Health, Sun Yat-sen University, Guangzhou, China.; School of Public Health, The University of Hong Kong, Hong Kong, China.; Institute of Applied Health Research, University of Birmingham, Birmingham, UK.; Greater Bay Area Public Health Research Collaboration, China.
Jazyk:	angličtina
Zdroj:	European psychiatry : the journal of the Association of European Psychiatrists [Eur Psychiatry] 2024 Aug 27; Vol. 67 (1), pp. e47. Date of Electronic Publication: 2024 Aug 27.
DOI:	10.1192/j.eurpsy.2024.1760
Abstrakt:	Background: Whether material deprivation-related childhood socio-economic disadvantages (CSD) and care-related adverse childhood experiences (ACE) have different impacts on depressive symptoms in middle-aged and older people is unclear. Methods: In the Guangzhou Biobank Cohort Study, CSD and ACE were assessed by 7 and 5 culturally sensitive questions, respectively, on 8,716 participants aged 50+. Depressive symptoms were measured by 15-item Geriatric Depression Scale (GDS). Multivariable linear regression, stratification analyses, and mediation analyses were done. Results: Higher CSD and ACE scores were associated with higher GDS score in dose-response manner (P for trend <0.001). Participants with one point increment in CSD and ACE had higher GDS score by 0.11 (95% confidence interval [CI], 0.09-0.14) and 0.41 (95% CI, 0.35-0.47), respectively. The association of CSD with GDS score was significant in women only (P for sex interaction <0.001; women: β (95% CI)=0.14 (0.11-0.17), men: 0.04 (-0.01 to 0.08)). The association between ACE and GDS score was stronger in participants with high social deprivation index (SDI) (P for interaction = 0.01; low SDI: β (95% CI)=0.36 (0.29-0.43), high SDI: 0.64 (0.48-0.80)). The proportion of association of CSD and ACE scores with GDS score mediated via education was 20.11% and 2.28%. Conclusions: CSD and ACE were associated with late-life depressive symptoms with dose-response patterns, especially in women and those with low adulthood socio-economic status. Education was a major mediator for CSD but not ACE. Eliminating ACE should be a top priority.
Databáze:	MEDLINE
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