Photodynamic therapy combined with voriconazole of extensive ulcer caused by Trichosporon asahii.

Autor: Chen S; Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou 510095, China., Luo Y; Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou 510095, China., Wu H; Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou 510095, China., Zhang J; Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou 510095, China., Li W; Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou 510095, China. Electronic address: 907327637@qq.com.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2024 Oct; Vol. 49, pp. 104313. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1016/j.pdpdt.2024.104313
Abstrakt: Trichosporon species are part of the normal microbiota of humans which can cause both superficial and invasive infections, primarily affecting immunocompetent and immunocompromised hosts, respectively. Giant ulcer caused by Trichosporon asahii is relatively uncommon in immunocompetent hosts. Increased drug resistance and biofilm-associated virulence makes the treatment of infectious ulcers challenging. Herein, we present a case of a massive ulcer caused by T. asahii which resulted in completed healing when treated with photodynamic therapy (PDT) and voriconazole. It provided the feasibility for PDT combined with antifungal drugs to treat similar refractory cases.
Competing Interests: Declaration of competing interest All authors declare no potential conflict of interest.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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