Upper endoscopy in elderly patients: a multicentre, cross-sectional study.

Autor: Zullo A; Gastroenterology and Endoscopy Unit, Nuovo Regina Margherita' Hospital, Rome, Italy., De Francesco V; Gastroenterology and Endoscopy Unit, Department of Medical and Surgical Sciences, Policlinico 'Riuniti Hospitals', University of Foggia, Viale L. Pinto, 71100, Foggia, Italy. vdefrancesco@alice.it., Amato A; Gastroenterology Unit, 'A. Manzoni' Hospital, Lecco, Italy., Bergna I; Gastroenterology Unit, 'A. Manzoni' Hospital, Lecco, Italy., Bendia E; Gastroenterology Unit, 'Riuniti' Hospital, Ancona, Italy., Giorgini G; Gastroenterology Unit, 'Riuniti' Hospital, Ancona, Italy., Buscarini E; Gastroenterology and Endoscopy Unit, 'Maggiore' Hospital, Crema, CR, Italy., Manfredi G; Gastroenterology and Endoscopy Unit, 'Maggiore' Hospital, Crema, CR, Italy., Cadoni S; Gastroenterology Unit, 'CTO' Hospital, Iglesias, Italy., Cannizzaro R; Experimental Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, PN, Italy., Realdon S; Experimental Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, PN, Italy., Ciuffi M; Endoscopy Unit, IRCCS CROB' Hospital, Rionero in Vulture, PZ, Italy., Ignomirelli O; Endoscopy Unit, IRCCS CROB' Hospital, Rionero in Vulture, PZ, Italy., Da Massa Carrara P; Gastroenterology Unit, ASL Toscana Nord-Ovest, 'San Luca' Hospital, Lucca, Italy., Finucci G; Gastroenterology Unit, ASL Toscana Nord-Ovest, 'San Luca' Hospital, Lucca, Italy., Di Somma A; Gastroenterology Unit, 'San Giovanni di Dio' Hospital, Gorizia, Italy., Frandina C; Gastroenterology Unit, 'S. Giovanni di Dio' Hospital, Crotone, Italy., Loria M; Gastroenterology Unit, 'S. Giovanni di Dio' Hospital, Crotone, Italy., Galeazzi F; Gastroenterology Unit, 'University' Hospital, Padua, Italy., Ferrara F; Gastroenterology Unit, 'University' Hospital, Padua, Italy., Gemme C; Gastroenterology Unit, 'SS. Antonio, Biagio e Cesare Arrigo' Hospital, Alessandria, Italy., Bertetti NS; Gastroenterology Unit, 'SS. Antonio, Biagio e Cesare Arrigo' Hospital, Alessandria, Italy., Gentili F; Gastroenterology Unit, Santa Maria' Hospital, Terni, Italy., Lotito A; Gastroenterology Unit, Santa Maria' Hospital, Terni, Italy., Germanà B; Gastroenterology and Endoscopy Unit, San Martino' Hospital, Belluno, Italy., Russo N; Gastroenterology and Endoscopy Unit, San Martino' Hospital, Belluno, Italy., Grande G; Gastroenterology Unit, Civile Baggiovara' Hospital, Modena, Italy., Conigliaro R; Gastroenterology Unit, Civile Baggiovara' Hospital, Modena, Italy., Cravero F; Gastroenterology Unit, Santa Croce e Carle' Hospital, Cuneo, Italy., Venezia G; Gastroenterology Unit, Santa Croce e Carle' Hospital, Cuneo, Italy., Marmo R; Gastroenterology Unit, 'L. Curto' Hospital, Polla, SA, Italy., Senneca P; Gastroenterology Unit, 'L. Curto' Hospital, Polla, SA, Italy., Milano A; Gastroenterology and Endoscopy Unit, 'SS. Annunziata' Hospital, Chieti, Italy., Efthymakis K; Gastroenterology and Endoscopy Unit, 'SS. Annunziata' Hospital, Chieti, Italy., Monica F; Gastroenterology Unit, 'San Giovanni di Dio' Hospital, Gorizia, Italy.; Gastroenterology and Endoscopy Unit, 'Cattinara' Hospital, Trieste, Italy., Montalto P; Gastroenterology Unit, ASL Toscana Centro, Pistoia, Italy., Lombardi M; Gastroenterology Unit, ASL Toscana Centro, Pistoia, Italy., Morelli O; Gastroenterology Unit, Santa Maria della Misericordia' Hospital, Perugia, Italy., Castellani D; Gastroenterology Unit, Santa Maria della Misericordia' Hospital, Perugia, Italy., Nigro D; Gastroenterology Unit, San Carlo' Hospital, Melfi, PZ, Italy., Festa R; Gastroenterology Unit, San Carlo' Hospital, Melfi, PZ, Italy., Peralta S; Gastroenterology Unit, 'AOU Policlinico' Hospital, Palermo, Italy., Grasso M; Gastroenterology Unit, 'AOU Policlinico' Hospital, Palermo, Italy., Privitera A; Gastroenterology Unit, 'Cannizzaro' Hospital, Catania, Italy., Di Stefano ME; Gastroenterology Unit, 'Cannizzaro' Hospital, Catania, Italy., Scaccianoce G; Gastroenterology Unit, 'Giovanni Paolo II' IRCCS, Bari, Italy., Loiacono M; Gastroenterology Unit, 'Giovanni Paolo II' IRCCS, Bari, Italy., Segato S; Gastroenterology Unit, ASST dei Sette Laghi' Hospital, Varese, Italy., Balzarini M; Gastroenterology Unit, ASST dei Sette Laghi' Hospital, Varese, Italy., Satta PU; Gastroenterology Unit, 'Brotzu' ARNAS, Cagliari, Italy., Lai M; Gastroenterology Unit, 'Brotzu' ARNAS, Cagliari, Italy., Fortunato F; Hygiene Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy., Manta R; Gastroenterology Unit, ASL Toscana Nord-Ovest, 'San Luca' Hospital, Lucca, Italy.
Jazyk: angličtina
Zdroj: Irish journal of medical science [Ir J Med Sci] 2024 Aug 26. Date of Electronic Publication: 2024 Aug 26.
DOI: 10.1007/s11845-024-03774-7
Abstrakt: Background: Both macroscopic and histological lesions are frequently detected at upper endoscopy in elderly patients. We assessed the prevalence of main endoscopic and histological alterations in elderly (> 65 years old) patients.
Methods: In this study, clinical, endoscopic and histological features of patients referred for upper endoscopy in clinical practice were retrieved. Both univariate and multivariate analyses were executed. Comparisons with previous data were performed.
Results: A total of 1336 underwent upper endoscopy in the 28 participating centres. At endoscopy, at least one macroscopic lesion was present in overall 420 (31.4%) patients. Erosive gastritis (13.3%) and erosive oesophagitis (9.8%) were the most prevalent lesions, whilst Barrett's oesophagus, gastric ulcer, duodenal ulcer and erosive duodenitis were observed in 1.8%, 2%, 1.4% and 3.1% patients, respectively. Nine (0.6%) cases of oesophageal, 25 (1.8%) gastric and 2 (0.1%) duodenal neoplasia were detected. At histology, Helicobacter pylori infection was diagnosed in 99 (15.9%) patients, and extensive precancerous lesions on gastric mucosa were detected in 80 (14.5%) patients. Endoscopic lesions were more frequent in males, at first endoscopy and in those with alarm symptoms and lower during PPI therapy. At multivariate analysis, PPI therapy significantly reduced the probability of finding endoscopic lesions (OR: 0.68, 95% CI: 0.46-0.99; P = 0.04), whilst neoplastic lesions were associated with presence of alarm symptoms (OR: 1.5, 95% CI: 1.1-2.1; P = 0.005).
Conclusions: We found that the frequency of erosive and neoplastic lesions remained high in elderly patients, whilst the prevalence of both H. pylori infection and peptic ulcer was decreased.
(© 2024. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)
Databáze: MEDLINE
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