The mark of success: The role of vaccine-induced skin scar formation for BCG and smallpox vaccine-associated clinical benefits.

Autor: Bæk O; University of Copenhagen, Copenhagen, Denmark., Schaltz-Buchholzer F; University of Southern Denmark, Copenhagen, Denmark., Campbell A; Telethon Kids Institute, Perth, Australia., Amenyogbe N; Telethon Kids Institute, Perth, Australia.; Dalhousie University, 5980 University Ave #5850, 4th floor Goldbloom Pavilion, Halifax, NS, B3K 6R8, Canada.; Bandim Health Project, Bissau, Guinea-Bissau., Campbell J; Central Perth Skin Clinic, Perth, Australia., Aaby P; Bandim Health Project, Bissau, Guinea-Bissau., Benn CS; University of Southern Denmark, Copenhagen, Denmark.; Bandim Health Project, Bissau, Guinea-Bissau., Kollmann TR; Telethon Kids Institute, Perth, Australia. tkollm@mac.com.; Dalhousie University, 5980 University Ave #5850, 4th floor Goldbloom Pavilion, Halifax, NS, B3K 6R8, Canada. tkollm@mac.com.; Bandim Health Project, Bissau, Guinea-Bissau. tkollm@mac.com.
Jazyk: angličtina
Zdroj: Seminars in immunopathology [Semin Immunopathol] 2024 Aug 26; Vol. 46 (5), pp. 13. Date of Electronic Publication: 2024 Aug 26.
DOI: 10.1007/s00281-024-01022-9
Abstrakt: Skin scar formation following Bacille Calmette-Guérin (BCG) or smallpox (Vaccinia) vaccination is an established marker of successful vaccination and 'vaccine take'. Potent pathogen-specific (tuberculosis; smallpox) and pathogen-agnostic (protection from diseases unrelated to the intentionally targeted pathogen) effects of BCG and smallpox vaccines hold significant translational potential. Yet despite their use for centuries, how scar formation occurs and how local skin-based events relate to systemic effects that allow these two vaccines to deliver powerful health promoting effects has not yet been determined. We review here what is known about the events occurring in the skin and place this knowledge in the context of the overall impact of these two vaccines on human health with a particular focus on maternal-child health.
(© 2024. The Author(s).)
Databáze: MEDLINE
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