Association between Periodontal Diseases and the Risk of Site-Specific Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.

Autor:	Wang Q; Department of Thoracic and Esophagus Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China., Gu WJ; Department of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China., Ning FL; Department of General Surgery, The Affiliated Xuzhou Hospital of Nanjing University of Chinese Medicine, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou, China., Sun M; Department of General Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China., Zhao ZG; Department of Surgical Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China., Abe MU; Department of Oral & Maxillofacial Surgery, The University of Tokyo Hospital, Tokyo, Japan.; Division for Health Service Promotion, The University of Tokyo, Tokyo 1138655, Japan., Li ZN; Department of Oromaxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Disease, Shenyang, China., Zhang CD; Department of Surgical Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.; Central Laboratory, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.; Lead contact.
Jazyk:	angličtina
Zdroj:	Journal of dental research [J Dent Res] 2024 Sep; Vol. 103 (10), pp. 962-972. Date of Electronic Publication: 2024 Aug 26.
DOI:	10.1177/00220345241263768
Abstrakt:	The association between periodontal diseases and the risk of gastrointestinal cancers, especially site-specific gastrointestinal cancers, remains unclear. Here, we comprehensively searched PubMed, EMBASE, Web of Science, and Google Scholar from inception to April 2024 to identify relevant studies. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with a random-effects model. Subgroup analyses and sensitivity analyses were conducted to confirm the robustness of the main findings in different populations. This study was reported according to PRISMA 2020 guidelines. In total, we identified 19 studies, including 16.6 million participants. Individuals with periodontal diseases had an increased risk of overall gastrointestinal cancers compared with those without periodontal diseases (HR 1.31, 95% CI 1.16-1.49). Periodontal diseases significantly increased the risk of esophageal cancer by 39% (HR 1.39, 95% CI 1.15-1.68), gastric cancer by 13% (HR 1.13, 95% CI 1.01-1.26), colorectal cancer by 21% (HR 1.21, 95% CI 1.05-1.39), pancreatic cancer by 35% (HR 1.35, 95% CI 1.00-1.82), and liver cancer by 9% (HR 1.09, 95% CI 1.04-1.13). The risk of gastrointestinal cancers was significantly increased by periodontitis (HR 1.45, 95% CI 1.14-1.85), gingivitis (HR 1.03, 95% CI 1.01-1.04), and periodontitis/gingivitis (HR 1.27, 95% CI 1.07-1.51). Furthermore, severe periodontal diseases showed a significantly increased risk of gastrointestinal cancer (HR 1.79, 95% CI 1.07-2.99). Results of sensitivity analyses for site-specific gastrointestinal cancers were robust with the main findings. In summary, periodontal diseases, especially severe periodontitis, increase the risk of overall and site-specific gastrointestinal cancers. Interventions to prevent and manage periodontal diseases may reduce the risk of developing gastrointestinal cancers. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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