Inhibition Effects of Some Non-Proteinogenic Amino Acid Derivatives on Carbonic Anhydrase Isoenzymes and Acetylcholinesterase: An In Vitro Inhibition and Molecular Modeling Studies.
| Autor: | Alım Z; Department of Chemistry, Faculty of Arts and Sciences, Kırşehir Ahi Evran University, Kırşehir, Türkiye., Rawat R; Department of Pharmaceutical Sciences, School of Health Sciences and Technology, UPES University, Dehradun, India., Adem Ş; Department of Chemistry, Faculty of Sciences, Çankırı Karatekin University, Çankırı, Türkiye., Eyüpoğlu V; Department of Chemistry, Faculty of Sciences, Çankırı Karatekin University, Çankırı, Türkiye., Akkemik E; Faculty of Engineering, Department of Food Engineering, Siirt University, Siirt, Türkiye. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry & biodiversity [Chem Biodivers] 2024 Aug 25, pp. e202401225. Date of Electronic Publication: 2024 Aug 25. |
| DOI: | 10.1002/cbdv.202401225 |
| Abstrakt: | Amino acid derivatives are molecules of interest for medicinal chemistry and drug design studies due to their important chemical properties. In this study, the inhibition effects of some non-proteinogenic amino acid derivatives (hippuric acid (A), N-(9-Fluorenylmethoxycarbonyl)-D-valine (B), N-Z-(1-Benzotriazolylcarbonyl) methylamine (C), (S)-N-Z-1-Benzotriazolylcarbonyl-2-phenylethylamine (D)) on carbonic anhydrase I (hCA-I), II (hCA-II) isoenzymes and acetylcholinesterase (AChE) activity, whose inhibitors are of vital pharmacological importance, were examined. While carbonic anhydrase (CA) inhibitors are effective molecule candidates for the treatment of many diseases from glaucoma to cancer, acetylcholinesterase inhibitors are target molecules for the treatment of Alzheimer's disease. According to the results of this study, compound D had a strong inhibitory effect on hCA-I (IC (© 2024 Wiley-VHCA AG, Zurich, Switzerland.) |
| Databáze: | MEDLINE |
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