Current green capillary electrophoresis and liquid chromatography methods for analysis of pharmaceutical and biomedical samples (2019-2023) - A review.

Autor: Jankech T; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, SK-845 45, Bratislava, Slovak Republic; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynska Dolina, Ilkovicova 6, SK-842 15, Bratislava, Slovak Republic., Gerhardtova I; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, SK-845 45, Bratislava, Slovak Republic; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynska Dolina, Ilkovicova 6, SK-842 15, Bratislava, Slovak Republic., Stefanik O; Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojarov 10, SK-832 32, Bratislava, Slovak Republic; Toxicological and Antidoping Center, Faculty of Pharmacy, Comenius University in Bratislava, Odbojarov 10, SK-832 32, Bratislava, Slovak Republic., Chalova P; Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojarov 10, SK-832 32, Bratislava, Slovak Republic; Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska Cesta 9, SK-845 45, Bratislava, Slovak Republic., Jampilek J; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, SK-845 45, Bratislava, Slovak Republic; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynska Dolina, Ilkovicova 6, SK-842 15, Bratislava, Slovak Republic., Majerova P; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, SK-845 45, Bratislava, Slovak Republic., Kovac A; Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska Cesta 9, SK-845 45, Bratislava, Slovak Republic., Piestansky J; Toxicological and Antidoping Center, Faculty of Pharmacy, Comenius University in Bratislava, Odbojarov 10, SK-832 32, Bratislava, Slovak Republic; Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojarov 10, SK-832 32, Bratislava, Slovak Republic. Electronic address: piestansky@fpharm.uniba.sk.
Jazyk: angličtina
Zdroj: Analytica chimica acta [Anal Chim Acta] 2024 Sep 22; Vol. 1323, pp. 342889. Date of Electronic Publication: 2024 Jun 20.
DOI: 10.1016/j.aca.2024.342889
Abstrakt: Separation analytical methods, including liquid chromatography (LC) and capillary electrophoresis (CE), in combination with an appropriate detection technique, are dominant and powerful approaches preferred in the analysis of pharmaceutical and biomedical samples. Recent trends in analytical methods are focused on activities that push them to the field of greenness and sustainability. New approaches based on the implementation of greener solvents, non-hazardous chemicals, and reagents have grown exponentially. Similarly, recent trends are pushed in to the strategies based on miniaturization, reduction of wastes, avoiding derivatization procedures, or reduction of energy consumption. However, the real greenness of the analytical method can be evaluated only according to an objective and sufficient metric offering complex results taking into account all twelve rules of green analytical chemistry (SIGNIFICANCE mnemonic system). This review provides an extensive overview of papers published in the area of development of green LC and CE methods in the field of pharmaceutical and biomedical analysis over the last 5 years (2019-2023). The main focus is situated on the metrics used for greenness evaluation of the methods applied for the determination of bioactive agents. It critically evaluates and compares the demands of the real applicability of the methods in quality control and clinical environment with the requirements of the green analytical chemistry (GAC). Greenness and practicality of the summarized methods are re-evaluated or newly evaluated with the use of the dominant metrics tools, i.e., Analytical GREEnness (AGREE), Green Analytical Procedure Index (GAPI), Blue Applicability Grade Index (BAGI), and Sample Preparation Metric of Sustainability (SPMS). Moreover, general conclusions and future perspectives of the greening procedures and greenness evaluation metrics systems are presented. This paper should provide comprehensive information to analytical chemists, biochemists, and it can also represent a valuable source of information for clinicians, biomedical or quality control laboratories interested in development of analytical methods based on greenness, practicality, and sustainability.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: