[Pre-extensively and extensively drug-resistant tuberculosis, in Libreville, Gabon].

Autor:	Kombila UD; Service de médecine interne, CHU de Libreville, faculté de médecine, université des sciences de la santé de Libreville, Libreville, Gabon; Faculté de médecine, université des sciences de la santé de Libreville, Libreville, Gabon. Electronic address: ulrichdavyk@gmail.com., Manomba Boulingui C; Service d'infectiologie, CHU de Libreville, Libreville, Gabon; Faculté de médecine, université des sciences de la santé de Libreville, Libreville, Gabon., N'Gomanda F; Service de médecine interne, CHU de Libreville, faculté de médecine, université des sciences de la santé de Libreville, Libreville, Gabon., Mouity Mavoungou JV; Service de médecine interne, CHU de Libreville, faculté de médecine, université des sciences de la santé de Libreville, Libreville, Gabon., Ngea Epossi CBH; Service de médecine interne, CHU de Libreville, faculté de médecine, université des sciences de la santé de Libreville, Libreville, Gabon., Bivigou N; Service de médecine interne, CHU de Libreville, faculté de médecine, université des sciences de la santé de Libreville, Libreville, Gabon., Tsioukaka S; Service de médecine interne, CHU de Libreville, faculté de médecine, université des sciences de la santé de Libreville, Libreville, Gabon., Tshisekedi JDD; Programme national de lutte contre la tuberculose (PNLT), Libreville, Gabon., Mahoumbou J; Programme national de lutte contre la tuberculose (PNLT), Libreville, Gabon., Boguikouma JB; Programme national de lutte contre la tuberculose (PNLT), Libreville, Gabon.
Jazyk:	francouzština
Zdroj:	Revue des maladies respiratoires [Rev Mal Respir] 2024 Oct; Vol. 41 (8), pp. 542-548. Date of Electronic Publication: 2024 Aug 22.
DOI:	10.1016/j.rmr.2024.06.011
Abstrakt:	Introduction: Very few studies have been devoted to extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) in Gabon. Aim: The aim of the present study is to present the epidemiology of pre-XDR and XDR TB and the evolution over time of patients with multidrug-resistant TB. Methods: This retrospective study covered the activities from 2019 to 2022 of the Nkembo anti-tuberculosis center. Results: Fifteen patients were eligible, including 11 (73.3%) pre-XDR patients and 4 (26.7%) XDR-TB patients. Three (20.0%) patients had HIV/TB co-infection. The sample consisted of 7 men (46.7%) and 8 women (53.3%), a sex ratio (M/F) of 0.87. The average age was 35.6 years, and the median 34 years, with extremes of 23 and 60 years. Eight patients (53.3%) represented new cases of pre-XDR or XDR-TB tuberculosis. The majority (60%; n=9) came from deprived neighborhoods with widespread promiscuity. The therapeutic success rate among pre-XDR patients was 4 (36.4%) versus 2 (50.0%) among XDR-TB patients. Reported mortality occurred 5 (33.3%) patients during treatment, including 3 pre-XDR and 2 XDR-TB patients. In all cases, they died before the end of the first trimester of follow-up. Conclusion: The high frequency of primary pre-extensively drug-resistant tuberculosis underscores the pervasiveness of resistance to anti-tuberculosis drugs and underlines a pressing need for detection of contact cases and early treatment. (Copyright © 2024 SPLF. Published by Elsevier Masson SAS. All rights reserved.)
Databáze:	MEDLINE
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