Agreement between frozen section and histopathology to detect malignancy in adnexal masses according to size and morphology by ultrasound.

Autor:	Amaral CA; Hospital de Clínicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto AlegreRS Brazil Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Pedrão PG; Hospital de Amor BarretosSP Brazil Hospital de Amor, Barretos, SP, Brazil., Godoy LR; Hospital de Amor BarretosSP Brazil Hospital de Amor, Barretos, SP, Brazil., Guimarães YM; Hospital de Amor BarretosSP Brazil Hospital de Amor, Barretos, SP, Brazil., Macedo CAP; Faculdade de Ciências da Saúde de Barretos Dr. Paulo Prata BarretosSP Brazil Faculdade de Ciências da Saúde de Barretos Dr. Paulo Prata, Barretos, SP, Brazil., Appel M; Hospital de Clínicas de Porto Alegre Universidade Federal do Rio Grande do Sul Porto AlegreRS Brazil Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Accorsi GS; Faculdade de Medicina de Catanduva CatanduvaSP Brazil Faculdade de Medicina de Catanduva, Catanduva, SP, Brazil., Zanon JR; Hospital de Amor BarretosSP Brazil Hospital de Amor, Barretos, SP, Brazil., Dos Reis R; Hospital de Amor BarretosSP Brazil Hospital de Amor, Barretos, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2024 Jul 26; Vol. 46. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024).
DOI:	10.61622/rbgo/2024rbgo63
Abstrakt:	Objective: Management of suspect adnexal masses involves surgery to define the best treatment. Diagnostic choices include a two-stage procedure for histopathology examination (HPE) or intraoperative histological analysis - intraoperative frozen section (IFS) and formalin-fixed and paraffin-soaked tissues (FFPE). Preoperative assessment with ultrasound may also be useful to predict malignancy. We aimed at determining the accuracy of IFS to evaluate adnexal masses stratified by size and morphology having HPE as the diagnostic gold standard. Methods: A retrospective chart review of 302 patients undergoing IFS of adnexal masses at Hospital de Clínicas de Porto Alegre, between January2005 and September2011 was performed. Data were collected regarding sonographic size (≤10cm or >10cm), characteristics of the lesion, and diagnosis established in IFS and HPE. Eight groups were studied: unilocular lesions; septated/cystic lesions; heterogeneous (solid/cystic) lesions; and solid lesions, divided in two main groups according to the size of lesion, ≤10cm or >10cm. Kappa agreement between IFS and HPE was calculated for each group. Results: Overall agreement between IFS and HPE was 96.1% for benign tumors, 96.1% for malignant tumors, and 73.3% for borderline tumors. Considering the combination of tumor size and morphology, 100% agreement between IFS and HPE was recorded for unilocular and septated tumors ≤10cm and for solid tumors. Conclusion: Stratification of adnexal masses according to size and morphology is a good method for preoperative assessment. We should wait for final HPE for staging decision, regardless of IFS results, in heterogeneous adnexal tumors of any size, solid tumors ≤10cm, and all non-solid tumors >10cm. Competing Interests: Conflicts to interest: this study is part of the requirements for a Master’s degree presented by Clarissa de Andrade Amaral in the Postgraduate Program at the Federal University of Rio Grande do Sul.
Databáze:	MEDLINE
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