Is oxidative stress - antioxidants imbalance the physiopathogenic core in pediatric obesity?

Autor:	Lupu A; Pediatrics, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Fotea S; Clinical Medical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, Galati, Romania., Jechel E; Pediatrics, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Starcea IM; Pediatrics, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Ioniuc I; Pediatrics, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Knieling A; Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Salaru DL; Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Sasaran MO; Pediatrics, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania., Cirstea O; Pediatrics, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Moldova., Revenco N; Pediatrics, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Moldova., Mihai CM; Pediatrics, Faculty of Medicine, 'Ovidius' University, Constanta, Romania., Lupu VV; Pediatrics, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Nedelcu AH; Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Aug 08; Vol. 15, pp. 1394869. Date of Electronic Publication: 2024 Aug 08 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1394869
Abstrakt:	Despite the early recognition of obesity as an epidemic with global implications, research on its pathogenesis and therapeutic approach is still on the rise. The literature of the 21st century records an excess weight found in up to 1/3 of children. Both the determining factors and its systemic effects are multiple and variable. Regarding its involvement in the potentiation of cardio-vascular, pulmonary, digestive, metabolic, neuro-psychic or even dermatological diseases, the information is already broadly outlined. The connection between the underlying disease and the associated comorbidities seems to be partially attributable to oxidative stress. In addition to these, and in the light of the recent COVID-19 pandemic, the role played by oxidative stress in the induction, maintenance and potentiation of chronic inflammation among overweight children and adolescents becomes a topic of interest again. Thus, this review's purpose is to update general data on obesity, with an emphasis on the physiopathological mechanisms that underlie it and involve oxidative stress. At the same time, we briefly present the latest principles of pathology diagnosis and management. Among these, we will mainly emphasize the impact played by endogenous and exogenous antioxidants in the evolutionary course of pediatric obesity. In order to achieve our objectives, we will refer to the most recent studies published in the specialized literature. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Lupu, Fotea, Jechel, Starcea, Ioniuc, Knieling, Salaru, Sasaran, Cirstea, Revenco, Mihai, Lupu and Nedelcu.)
Databáze:	MEDLINE
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