Cortical lobar volume reductions associated with homocysteine-related subcortical brain atrophy and poorer cognition in healthy aging.

Autor:	Song H; Department of Psychology, University of Arizona, Tucson, AZ, United States.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States., Bharadwaj PK; Department of Psychology, University of Arizona, Tucson, AZ, United States.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States., Raichlen DA; Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, United States., Habeck CG; Cognitive Neuroscience Division, Department of Neurology and Taub Institute, Columbia University, New York, NY, United States., Grilli MD; Department of Psychology, University of Arizona, Tucson, AZ, United States.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States.; Department of Neurology, University of Arizona, Tucson, AZ, United States., Huentelman MJ; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States.; Neurogenomics Division, The Translational Genomics Research Institute (TGen), Phoenix, AZ, United States.; Arizona Alzheimer's Consortium, Phoenix, AZ, United States., Hishaw GA; Department of Neurology, University of Arizona, Tucson, AZ, United States., Trouard TP; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States.; Arizona Alzheimer's Consortium, Phoenix, AZ, United States.; Department of Biomedical Engineering, University of Arizona, Tucson, AZ, United States., Alexander GE; Department of Psychology, University of Arizona, Tucson, AZ, United States.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States.; Arizona Alzheimer's Consortium, Phoenix, AZ, United States.; Department of Psychiatry, University of Arizona, Tucson, AZ, United States.; Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs, University of Arizona, Tucson, AZ, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2024 Aug 07; Vol. 16, pp. 1406394. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024).
DOI:	10.3389/fnagi.2024.1406394
Abstrakt:	Homocysteine (Hcy) is a cardiovascular risk factor implicated in cognitive impairment and cerebrovascular disease but has also been associated with Alzheimer's disease. In 160 healthy older adults (mean age = 69.66 ± 9.95 years), we sought to investigate the association of cortical brain volume with white matter hyperintensity (WMH) burden and a previously identified Hcy-related multivariate network pattern showing reductions in subcortical gray matter (SGM) volumes of hippocampus and nucleus accumbens with relative preservation of basal ganglia. We additionally evaluated the potential role of these brain imaging markers as a series of mediators in a vascular brain pathway leading to age-related cognitive dysfunction in healthy aging. We found reductions in parietal lobar gray matter associated with the Hcy-SGM pattern, which was further associated with WMH burden. Mediation analyses revealed that slowed processing speed related to aging, but not executive functioning or memory, was mediated sequentially through increased WMH lesion volume, greater Hcy-SGM pattern expression, and then smaller parietal lobe volume. Together, these findings suggest that volume reductions in parietal gray matter associated with a pattern of Hcy-related SGM volume differences may be indicative of slowed processing speed in cognitive aging, potentially linking cardiovascular risk to an important aspect of cognitive dysfunction in healthy aging. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Song, Bharadwaj, Raichlen, Habeck, Grilli, Huentelman, Hishaw, Trouard and Alexander.)
Databáze:	MEDLINE
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