Impact of rs599839 Polymorphism on Coronary Artery Disease Risk in Saudi Diabetic Patients.

Autor: Bogari NM; Department of Medical Genetics Faculty of Medicine Umm Al-Qura University, Makkah, Saudi Arabia., Babalghith AO; Department of Medical Genetics Faculty of Medicine Umm Al-Qura University, Makkah, Saudi Arabia., Azher ZA; Department of Medical Genetics Faculty of Medicine Umm Al-Qura University, Makkah, Saudi Arabia., Mufti AH; Department of Medical Genetics Faculty of Medicine Umm Al-Qura University, Makkah, Saudi Arabia., Bouazzaoui A; Department of Medical Genetics Faculty of Medicine Umm Al-Qura University, Makkah, Saudi Arabia.; Science and Technology Unit Umm Al Qura University, Makkah, Saudi Arabia., Banni H; Department of Medical Genetics Faculty of Medicine Umm Al-Qura University, Makkah, Saudi Arabia., Madkhali AA; Department of Pathology and Laboratory Medicine Cytogenetics Lab King Abdulaziz Medical City Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia., Alahmadi A; Department of Pathology and Laboratory Medicine King Faisal Hospital, Makkah, Saudi Arabia., Allam RM; Department of Clinical Pathology Faculty of Medicine Zagazig University, Zagazig, Egypt.
Jazyk: angličtina
Zdroj: Disease markers [Dis Markers] 2024 Aug 07; Vol. 2024, pp. 8278727. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024).
DOI: 10.1155/2024/8278727
Abstrakt: Background: Coronary artery diseases may be affected by several genetic and nongenetic factors. Single-nucleotide polymorphism (SNP) rs599839 and type 2 diabetes mellitus (T2DM) can affect the occurrence and severity of coronary artery disease (CAD).
Methods: Our aim was to investigate how T2DM and the rs599839 variant affected serum lipid levels and the degree of CAD patients' coronary artery stenosis. rs599839 polymorphism genotyping was done on Saudi patients with coronary angiography performed previously. Patients enrolled were divided into group A (360 DM patients), group B (225 DM patients with CAD), and group C (190 healthy volunteers as control).
Results: Individuals with diabetes and CAD who possessed the GG genotype in rs599839 exhibited markedly reduced means of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG; 224.5, 116.2, and 221.4 versus 251.6, 131.3, and 261.7 mg/dl, p =0.003, 0.007, and 0.025, respectively) than AA genotype. The odds ratio and the confidence interval of 95% for G allele carriers of rs599839 were OR = 0.62, 95% CI: 0.41-0.82, and p =0.003, among diabetic patients with CAD.
Conclusions: In patients with diabetic CAD, the locus 1p13.3 polymorphism rs599839 was found to be substantially correlated with serum lipid levels. Furthermore, among Saudi patients with diabetes, the G allele of rs599839 variant lowers the CAD risk.
Competing Interests: There is nothing relevant to disclose regarding the authors' non-financial or financial interests.
(Copyright © 2024 Neda M. Bogari et al.)
Databáze: MEDLINE
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