Possible Association between Behçet's Disease and Periodontal diseases.

Autor: Orduyilmaz F; Topraklik Oral and Dental Health Center, Ankara, Turkey., Ozmeric N; Faculty of Dentistry, Department of Periodontology, Gazi University, Ankara, Turkey. nurdan@gazi.edu.tr., Elgun S; Faculty of Medicine, Department of Medical Biochemistry, Ankara University, Ankara, Turkey., Gürbüz S; Faculty of Dentistry, Department of Periodontology, Gazi University, Ankara, Turkey., Kucuk H; Faculty of Medicine, Department of Rheumatology, Gazi University, Ankara, Turkey., Bitik B; Faculty of Medicine, Department of Rheumatology, Baskent University, Ankara, Turkey., Tufan A; Faculty of Medicine, Department of Rheumatology, Gazi University, Ankara, Turkey., Göker B; Faculty of Medicine, Department of Rheumatology, Gazi University, Ankara, Turkey.
Jazyk: angličtina
Zdroj: BMC oral health [BMC Oral Health] 2024 Aug 20; Vol. 24 (1), pp. 964. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1186/s12903-024-04749-x
Abstrakt: Aim: This study explores the connection between Behçet's disease (BD), characterized by persistent oral and genital ulcers alongside iritis, and periodontal disease. It examines the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nitric oxide (NO) in gingival crevicular fluid (GCF) and saliva.
Methods: Forty Behçet's patients with gingivitis or periodontitis and 47 patients with either gingivitis or periodontitis but without BD were studied. Periodontal status was recorded with standard clinical indexes. GCF and saliva samples were obtained. NO, IL-1β and TNF-α levels were analysed. Current Behçet's symptoms and medications usage were recorded.
Results: Mean salivary IL-1β was elevated (p = .045), and mean NO level was decreased in BD patients with gingivitis compared to patients without BD (p = .000). In contrast, mean NO level in crevicular fluid was higher in Behçet's patients with periodontitis than in patients without BD (p = .009). Furthermore, among Behçet's patients, those with vascular involvement had lower salivary NO level compared to patients without vascular involvement (p = .000).
Conclusions: Based on our findings, the elevated levels of IL-1β in the saliva of Behçet's patients with gingivitis, along with the decreased NO level, indicate an altered inflammatory response in the oral cavity.
(© 2024. The Author(s).)
Databáze: MEDLINE
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