Erythrocyte deformability correlates with systemic inflammation.

Autor: Jacob C; Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK; Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: c.jacob@soton.ac.uk., Piyasundara L; Haematology Department, Oxford University Hospitals NHS Trust, Oxford, England, UK., Bonello M; Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK; Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Nathan M; Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Kaninia S; Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK; Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Varatharaj A; Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK., Roy N; Haematology Department, Oxford University Hospitals NHS Trust, Oxford, England, UK., Galea I; Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK; Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Jazyk: angličtina
Zdroj: Blood cells, molecules & diseases [Blood Cells Mol Dis] 2024 Nov; Vol. 109, pp. 102881. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1016/j.bcmd.2024.102881
Abstrakt: Recent evidence suggests that systemic conditions, particularly those associated with inflammation, can affect erythrocyte deformability in the absence of haematological conditions. In this exploratory study, we investigated the relationship between systemic inflammatory status and erythrocyte deformability (using osmotic gradient ektacytometry) in a heterogenous study population consisting of individuals with no medical concerns, chronic conditions, and acute illness, providing a wide range of systemic inflammation severity. 22 participants were included in a prospective observational study. Maximum Elongation Index (EI max ) in ektacytometry served as the readout for erythrocyte deformability. Inflammatory status was assessed using C-reactive protein (CRP) and self-reported symptoms associated with inflammatory activation (Sickness Questionnaire Scores, SicknessQ). In a univariate linear regression, both CRP and SicknessQ scores significantly predicted EI max (CRP: F(1,20) = 7.751, p < 0.05 (0.011), R 2  = 0.279; SicknessQ: F(1,18) = 4.831, p < 0.05 (0.041), R 2  = 0.212). Sensitivity analyses with multivariable linear regression correcting for age showed concordant findings. Results suggest a linear relationship between erythrocyte deformability and biochemical and clinical markers of systemic inflammation. Replication of findings in a larger study, and mechanisms and clinical consequences need further in investigation.
Competing Interests: Declaration of competing interest The authors declare no potential conflicts of interest relevant to this work.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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