| Autor: |
Moutaouakkil Y; Laboratoire de Pharmacologie-Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohamed V de Rabat, 10001 Rabat, Maroc., Mounir R; Laboratoire de Biochimie, CHU Ibn Sina, Rabat, Maroc., El Cadi MA; Laboratoire de Pharmacologie-Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohamed V de Rabat, 10001 Rabat, Maroc., Lamsaouri J; Laboratoire de Pharmacologie-Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohamed V de Rabat, 10001 Rabat, Maroc., Bousliman Y; Laboratoire de Pharmacologie-Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohamed V de Rabat, 10001 Rabat, Maroc., ElJaoudi R; Laboratoire de Pharmacologie-Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohamed V de Rabat, 10001 Rabat, Maroc. |
| Jazyk: |
francouzština |
| Zdroj: |
Annales de biologie clinique [Ann Biol Clin (Paris)] 2024 Aug 30; Vol. 82 (3), pp. 254-265. |
| DOI: |
10.1684/abc.2024.1898 |
| Abstrakt: |
Present in quantities ranging from hundreds of milligrams to several grams in various environmental compartments, trace metal elements (TMEs), formerly known as "heavy metals," have been the subject of much discussion in recent years due to their major toxicological impact on human health. They are divided into essential elements such as iron, zinc, copper, selenium, manganese, and toxic elements such as mercury, cadmium, lead, lithium, and arsenic. Essential trace elements play a vital role in the body, and their deficiency can alter important physiological functions, while toxic elements have no physiological role and can lead to serious illnesses. However, essential elements can also cause intoxication depending on their concentrations and chemical forms. The industrialization of the modern world exposes the global population to high concentrations of trace elements that can be toxic in the short or long term. These TMEs enter the human body through various pathways (inhalation, ingestion, or dermal contact). The clinical manifestations of TME intoxications are highly varied and nonspecific, making their diagnosis and management difficult. Inductively coupled plasma mass spectrometry (ICP-MS) allows the detection of TME intoxications. Indeed, it enables the simultaneous quantification of around thirty trace metal elements in biological media. Thus, it has led to the establishment of a new approach: the metal profile, which has many applications in clinical biology and clinical, forensic, occupational, or environmental toxicology. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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