Nontuberculosis mycobacteria (NTM) infections in patients with leukemia: a single center case series.

Autor:	Marvin-Peek J; Department of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Sasaki K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Kontoyiannis DP; Department of Infectious Disease, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Adachi J; Department of Infectious Disease, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Ohanian M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Takahashi K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Issa GC; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Kornblau S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Abbas HA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2024 Aug 01; Vol. 11, pp. 1402897. Date of Electronic Publication: 2024 Aug 01 (Print Publication: 2024).
DOI:	10.3389/fmed.2024.1402897
Abstrakt:	Patients with leukemia experience profound immunosuppression both from their underlying disease as well as chemotherapeutic treatment. Little is known about the prevalence and clinical presentation of nontuberculous mycobacteria (NTM) in this patient population. We identified six cases of NTM infection from 29,743 leukemia patients who had acid-fast bacilli (AFB) cultures. Four cases had bloodstream infections and five had disseminated disease, including one who presented with an unusual case of diffuse cellulitis/myositis. All patients were lymphopenic at time of diagnosis, and two patients ultimately died from their NTM infection. NTM infections are a rare, but potentially life-threatening infection in patients with leukemia. Sending AFB cultures early is important to direct appropriate antimicrobial therapy and allow for future leukemia-directed therapy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Marvin-Peek, Sasaki, Kontoyiannis, Adachi, Ohanian, Takahashi, Issa, Kornblau and Abbas.)
Databáze:	MEDLINE
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