Frequencies of chromosomal aberrations and related biochemical parameters in welders.

Autor: Pavel V; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Videnska 1083, Prague 142 20, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague 128 00, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen 306 05, Czech Republic. Electronic address: pavel.vodicka@iem.cas.cz., Ludovit M; Biomedical Center Martin, Central Laboratories and Scientific Research Groups, Comenius University in Bratislava, Jessenius Faculty of Medicine, Martin 036 01, Slovakia., Marian G; Biomedical Center Martin, Bioinformatic Center, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia., Jela V; Hospital Agel, Zvolen, Slovakia., Ludmila V; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Videnska 1083, Prague 142 20, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague 128 00, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen 306 05, Czech Republic., Erika H; Biomedical Center Martin, Central Laboratories and Scientific Research Groups, Comenius University in Bratislava, Jessenius Faculty of Medicine, Martin 036 01, Slovakia; Department of Medical Biology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia.
Jazyk: angličtina
Zdroj: Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2024 Aug-Sep; Vol. 898, pp. 503806. Date of Electronic Publication: 2024 Jul 25.
DOI: 10.1016/j.mrgentox.2024.503806
Abstrakt: Stainless steel welders are exposed to heavy filler metals. We evaluated the concentration of these metals in whole blood and urine, and the relevant biochemical parameters in relation to the total chromosomal aberrations (CAs), chromatid-type (CTA-type, CTAs) and chromosome-type (CSA-type, CSAs), in 117 welders and control individuals. Statistically higher concentrations of the total Cr, Ni and Mn were observed in whole blood and urine of welders, and the concentrations were higher in welders who smoked. On the contrary, concentrations of urinary heavy metals Cr and Mn adjusted for creatinine were significantly higher in the control groups. A statistically higher frequency of total CAs was observed in the whole group of welders, and also in the non-smoking welders, as compared to controls. The frequency of total CAs significantly correlated with the concentration of Cr, Ni and Mn in whole blood (R=0.61, P˂0.0001, R=0.33, P˂0.0001 and R=0.66, P˂0.0001, respectively), with urinary concentrations of Ni and Mn (R=0.27, P=0.003 and R=0.28, P=0.003, respectively) and with urinary concentrations of Cr, Ni and Mn adjusted for creatinine (R=0.22, P=0.029, R=0.26, P=0.005 and R=0.20, P=0.030, respectively). Likewise, the frequency of CTA-types significantly correlated with the concentration of Cr and Mn in whole blood (R=0.31, P=0.0007 and R=0.34, P=0.0002). The frequency of CSA-types significantly correlated with concentrations of Cr, Ni and Mn in whole blood (R=0.43, P˂0.0001, R=0.38, P˂0.0001 and R=0.46, P˂0.0001, respectively). The statistically higher values of serum creatinine and total bilirubin were detected in all welders, as well as in smokers when compared to the corresponding controls. The exposure to heavy metals in welders increased the frequencies of CAs and altered the balance between urinary excretion of heavy metals and their possible accumulation.
Competing Interests: Declaration of Competing Interest To our best knowledge neither of the co-authors has any actual or potential competing interests regarding this manuscript. The study was conducted in agreement with ethical principles on strictly coded samples and the identity of the participants was not disclosed.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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