Hesperetin-7-O-rhamnoglucoside ameliorates dichlorvos-facilitated cardiotoxicity in rats by counteracting ionoregulatory, ion pumps, redox, and lipid homeostasis disruptions.

Autor:	Akamo AJ; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.; Clinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria., Ojelabi AO; Clinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria., Somade OT; Clinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria., Kehinde IA; Department of Pure and Applied Botany, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria., Taiwo AM; Department of Environmental Management and Toxicology, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria., Olagunju BA; Clinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria., Akinsanya MA; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria., Adebisi AA; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria., Adekunbi TS; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria., Adenowo AF; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria., Anifowose F; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria., Ajagun-Ogunleye OM; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria., Eteng OE; Clinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria., Akintunde JK; Clinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria., Ugbaja RN; Clinical Biochemistry and Mechanistic Toxicology Research Cluster, Department of Biochemistry, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2024 Jul 19; Vol. 13, pp. 101698. Date of Electronic Publication: 2024 Jul 19 (Print Publication: 2024).
DOI:	10.1016/j.toxrep.2024.101698
Abstrakt:	The contamination of edible agricultural goods with pesticides, including dichlorvos (DVDP), poses a substantial public health risk, promoting severe morbidity and mortality, especially in developing countries. It has been shown that hesperidin (hesperetin-7-O-rhamnoglucoside or Hes-7-RGlc) preserves cytomembrane, redox, and lipid homeostasis; unfortunately, its function on dichlorvos-incited heart damage has not been investigated. This work explored the ameliorative influence of Hes-7-RGlc on DVDP-activated cardiotoxicity. For this end, forty-two rats were randomly appropriated into seven groups (6 rats/group): Control, DVDP alone (8 mg.kg⁻¹day⁻¹), DVDP supplied with either Hes-7-RGlc (50 and 100 mg.kg⁻¹day⁻¹) or the reference medication atropine (0.2 mg.kg⁻¹day⁻¹), and Hes-7-RGlc alone (50 and 10 mg.kg⁻¹day⁻¹) were the seven groups investigated. DVDP was administered orally for seven days, followed by fourteen days of Hes-7-RGlc therapy. Then the rats were euthanized, and their blood and hearts were removed. Hes-7-RGlc chemotherapy substantially (p<0.05) restored DVDP-elicited dynamics in plasma and cardiac/myocardium creatine kinase isoenzyme (CK-MB), major lipids (cholesterol, triacylglycerol, and phospholipids), electrolytes (Na⁺, K⁺, Ca²⁺, Mg²⁺, Cl⁻), and total protein. Hes-7-RGlc remedy decidedly (p<0.05) abolished DDVP-stimulated amplification in the cardiac concentration of H₂O₂, NO and malondialdehyde; annulled DVDP-educed decreases in heart GSH levels, activities of GST, SOD, catalase, and glutathione peroxidase, ion transporters (Na⁺/K⁺-ATPase and Ca²⁺/Mg²⁺-ATPase), ALT, AST, ALP, and LDH-1. Collectively, Hes-7-RGlc can be advocated as a natural supplementary candidate and blocker of DVDP-provoked heart deficits via its capacity to reverse disruptions of electrolytes, ion pumps, redox status, and lipid homeostasis. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper (© 2024 The Authors.)
Databáze:	MEDLINE
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