Anti-Amyloid Aggregation and Anti-Hyperglycemic Activities of Novel Ruthenium Uracil Schiff Base Compounds.

Autor: Makanyane DM; School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg, South Africa., Mabuza LP; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Ngubane P; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Khathi A; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Mambanda A; School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg, South Africa., Booysen IN; School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2024 Aug 13, pp. e202400477. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1002/cmdc.202400477
Abstrakt: The formation and characterization of new diamagnetic ruthenium uracil mono-imine compounds: [(η 6 -p-cymene)Ru II (L)Cl][BF 4 ] (L=H 2 urpda=5-((pyridin-2-yl)methyleneamino)-6-aminouracil) for 1, urdpy=6-amino-1,3-dimethyl-5-((pyridin-2-ylmethylene)amino)uracil) for 2 or urqda=5-((quinolin-2-yl)methyleneamino)-6-aminouracil) for 3); cis-[Ru(bipy) 2 (urpy)](BF 4 ) 2 (4) (urpy=5-((pyridin-2-yl)methyleneamino)uracil) and cis-[Ru(bipy) 2 (dapd)] (5) (H 2 dadp=5,6-diaminouracil) are described. A ruthenium(IV) uracil Schiff base compound, trans-[Ru(urpda)(PPh 3 )Cl 2 ] (6) was also formed. Various physicochemical techniques were utilized to characterize the novel ruthenium compounds. Similarly, the stabilities of 1-3 and 6 monitored in chloro-containing and the non-coordinating solvent, dichloromethane show that they are kinetically inert, whereas, in a high nucleophilic environment, the chloride co-ligands of these ruthenium complexes were rapidly substituted by DMSO. In contrast, the substitution of the labile co-ligands for these ruthenium complexes by DMSO molecules in a high chloride content was suppressed. Solution chemical reactivities of the different ruthenium complexes were rationalized by density functional theory computations. Furthermore, the binding affinities and strengths between BSA and the respective ruthenium complexes were monitored using fluorescence spectroscopy. In addition, the in vitro anti-diabetic activities of the novel metal complexes were assessed in selected skeletal muscle and liver cell lines.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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