Hebbian plasticity induced by temporally coincident BCI enhances post-stroke motor recovery.

Autor: Krueger J; Neurocybernetics and Rehabilitation, Department of Neurology, Otto von Guericke University, Magdeburg, Germany., Krauth R; Neurocybernetics and Rehabilitation, Department of Neurology, Otto von Guericke University, Magdeburg, Germany., Reichert C; Leibniz Institute for Neurobiology, Magdeburg, Germany., Perdikis S; School of Computer Science and Electronic Engineering, University of Essex, Colchester, UK., Vogt S; Neurocybernetics and Rehabilitation, Department of Neurology, Otto von Guericke University, Magdeburg, Germany.; Department of Neurology, Otto von Guericke University, Magdeburg, Germany.; Department of Psychosomatic Medicine and Psychotherapy, Otto von Guericke University, Magdeburg, Germany., Huchtemann T; Neurocybernetics and Rehabilitation, Department of Neurology, Otto von Guericke University, Magdeburg, Germany.; Department of Neurology, Otto von Guericke University, Magdeburg, Germany.; Department of Neurology, University Hospital Münster, Münster, Germany., Dürschmid S; Leibniz Institute for Neurobiology, Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), Otto von Guericke University, Magdeburg, Germany., Sickert A; Neurorehabilitation Centre, MEDIAN, Magdeburg, Germany., Lamprecht J; Neurorehabilitation Centre, MEDIAN, Magdeburg, Germany.; Health and Care Sciences, Martin Luther University Halle-Wittenberg, Halle, Germany., Huremovic A; Neurorehabilitation Centre, MEDIAN, Magdeburg, Germany.; Department of Neurology, Ingolstadt Hospital, Ingolstadt, Germany., Görtler M; Department of Neurology, Otto von Guericke University, Magdeburg, Germany., Nasuto SJ; Biomedical Engineering, University of Reading, Reading, UK., Tsai IC; Neurocybernetics and Rehabilitation, Department of Neurology, Otto von Guericke University, Magdeburg, Germany., Knight RT; Helen Wills Neuroscience Institute, University of California -Berkeley, Berkeley, USA.; Department of Psychology, University of California -Berkeley, Berkeley, USA., Hinrichs H; Leibniz Institute for Neurobiology, Magdeburg, Germany.; Department of Neurology, Otto von Guericke University, Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), Otto von Guericke University, Magdeburg, Germany., Heinze HJ; Leibniz Institute for Neurobiology, Magdeburg, Germany.; University Hospital Magdeburg, Otto von Guericke University, Magdeburg, Germany., Lindquist S; Department of Neurology, Pfeiffersche Stiftung, Magdeburg, Germany., Sailer M; Neurorehabilitation Centre, MEDIAN, Magdeburg, Germany., Millán JDR; Chandra Family Department of Electrical and Computer Engineering, The University of Texas at Austin, Austin, USA.; Department of Neurology, The University of Texas at Austin, Austin, USA.; Mulva Clinic for the Neurosciences, The University of Texas at Austin, Austin, USA.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, USA., Sweeney-Reed CM; Neurocybernetics and Rehabilitation, Department of Neurology, Otto von Guericke University, Magdeburg, Germany. catherine.sweeney-reed@med.ovgu.de.; Center for Behavioral Brain Sciences (CBBS), Otto von Guericke University, Magdeburg, Germany. catherine.sweeney-reed@med.ovgu.de.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 12; Vol. 14 (1), pp. 18700. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1038/s41598-024-69037-8
Abstrakt: Functional electrical stimulation (FES) can support functional restoration of a paretic limb post-stroke. Hebbian plasticity depends on temporally coinciding pre- and post-synaptic activity. A tight temporal relationship between motor cortical (MC) activity associated with attempted movement and FES-generated visuo-proprioceptive feedback is hypothesized to enhance motor recovery. Using a brain-computer interface (BCI) to classify MC spectral power in electroencephalographic (EEG) signals to trigger FES-delivery with detection of movement attempts improved motor outcomes in chronic stroke patients. We hypothesized that heightened neural plasticity earlier post-stroke would further enhance corticomuscular functional connectivity and motor recovery. We compared subcortical non-dominant hemisphere stroke patients in BCI-FES and Random-FES (FES temporally independent of MC movement attempt detection) groups. The primary outcome measure was the Fugl-Meyer Assessment, Upper Extremity (FMA-UE). We recorded high-density EEG and transcranial magnetic stimulation-induced motor evoked potentials before and after treatment. The BCI group showed greater: FMA-UE improvement; motor evoked potential amplitude; beta oscillatory power and long-range temporal correlation reduction over contralateral MC; and corticomuscular coherence with contralateral MC. These changes are consistent with enhanced post-stroke motor improvement when movement is synchronized with MC activity reflecting attempted movement.
(© 2024. The Author(s).)
Databáze: MEDLINE
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