Cutting Edge: Retinoic Acid Promotes Brain-homing of CD8+ T Cells during Congenital Cytomegalovirus Infection.
| Autor: | Hilt ZT; Department of Microbiology and Immunology, Cornell University, Ithaca, NY., Charles W; Department of Microbiology and Immunology, Cornell University, Ithaca, NY., Ali T; Department of Microbiology and Immunology, Cornell University, Ithaca, NY., Smith CV; Department of Microbiology and Immunology, Cornell University, Ithaca, NY., Zhang S; Department of Microbiology and Immunology, Cornell University, Ithaca, NY., Wesnak SP; Department of Microbiology and Immunology, Cornell University, Ithaca, NY., Smith NL; Department of Microbiology and Immunology, Cornell University, Ithaca, NY., Rudd BD; Department of Microbiology and Immunology, Cornell University, Ithaca, NY. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Oct 01; Vol. 213 (7), pp. 933-939. |
| DOI: | 10.4049/jimmunol.2400150 |
| Abstrakt: | The most common congenital viral infection is CMV, which leads to numerous neurologic disabilities. Using a mouse model of congenital CMV, we previously determined that Ag-specific CD8+ T cells traffic to the brain in a CCR9-dependent manner. The mechanism by which these CD8+ T cells acquire a CCR9-dependent "brain-tropic" phenotype remains unclear. In this study, we identify the key factor that imprints brain homing specificity on CD8+ T cells, the source of production, and the location where CCR9 expression is induced. Specifically, we discovered that CCR9 is induced on CD8+ T cells by retinoic acid-producing CD8α+ dendritic cells in the cervical lymph node postinfection. We found that retinoic acid is important for CD8+ T cells to establish tissue residency in the brain. Collectively, our data expand the role of retinoic acid during infection and mechanistically demonstrate how CD8+ T cells are primed to protect the brain during congenital viral infection. (Copyright © 2024 by The American Association of Immunologists, Inc.) |
| Databáze: | MEDLINE |
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