ABO/Rh Blood Group and Cervical Cancer Survival: Results from Our Own and Other Studies.

Autor:	Mandato VD; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Torricelli F; Laboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy., Mastrofilippo V; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Vacca I; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Melli B; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.; Molecular Pathology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, 41121 Modena, Italy., Generali M; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Annunziata G; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Pirillo D; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., D'Ippolito G; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Ciarlini G; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Aguzzoli L; Unit of Obstetrics and Gynecologic Oncology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Jazyk:	angličtina
Zdroj:	Journal of Cancer [J Cancer] 2024 Jul 09; Vol. 15 (15), pp. 4777-4788. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).
DOI:	10.7150/jca.95245
Abstrakt:	Background: Cervical cancer is the most common genital cancer worldwide and is mainly caused by a persistent human papillomavirus infection. Well-known prognostic factors are age, histology, stage, stromal invasion, tumor size, and tumor grade. The relationship between the ABO and Rh system with cervical cancer has been studied since the 1950s, though without obtaining clear results. Here we investigated the association between the ABO blood group and Rh system and consecutively treated cervical cancer patients in our department. Methods: Clinical charts of cervical cancer patients treated and followed from 2010 to 2021 were checked for inclusion and exclusion criteria. Clinical and pathological data were recorded in a separate, anonymous, password-protected electronic database. All relevant data were extrapolated and used for final analysis. Results: A population of 143 cervical cancer patients was analyzed in this study. 47.6% (68/143) were blood group O, 36.4% (52/143) were blood group A, 8.4% (12/143) were blood group AB, and 7.7% (11/143) were blood group B. 14.9% (21/141) were RhD negative, while 85.1% (120/141) were RhD positive. No significant association was found between the ABO group and survival. However, patients with blood types B and AB had a higher BMI than the other blood types. RhD-negative patients exhibited a lower age at diagnosis (P=0.035) and had a higher overall survival compared to RhD-positive patients. Conclusions: The RhD factor appears to influence cervical cancer OS, but the data are too weakly significant to draw a definitive conclusion. Further studies with larger samples are needed to confirm this finding and to investigate the true impact of blood groups in female cancers. Competing Interests: Competing Interests: The authors have declared that no competing interest exists. (© The author(s).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu