A worldwide study of white matter microstructural alterations in people living with Parkinson's disease.

Autor: Owens-Walton C; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Conor.Owens-Walton@loni.usc.edu., Nir TM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Al-Bachari S; Lancaster Medical School, Lancaster University, Lancaster, UK., Ambrogi S; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Anderson TJ; Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.; New Zealand Brain Research Institute, Christchurch, New Zealand.; Neurology Department, Te Whatu Ora-Health New Zealand Waitaha Canterbury, Christchurch, New Zealand., Aventurato ÍK; Department of Neurology, University of Campinas-UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Cendes F; Department of Neurology, University of Campinas-UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Chen YL; Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC.; Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan, ROC., Ciullo V; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Cook P; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Dalrymple-Alford JC; New Zealand Brain Research Institute, Christchurch, New Zealand.; Te Kura Mahi ā- Hirikapo | School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand., Dirkx MF; Department of Neurology and Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., Druzgal J; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA., Emsley HCA; Lancaster Medical School, Lancaster University, Lancaster, UK.; Department of Neurology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK., Guimarães R; Department of Neurology, University of Campinas-UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Haroon HA; Division of Psychology, Communication & Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance & University of Manchester, Manchester, UK., Helmich RC; Department of Neurology and Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands., Hu MT; Oxford Parkinson's Disease Centre, Nuffield, Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, UK., Johansson ME; Department of Neurology and Center of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands., Kim HB; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA., Klein JC; Oxford Parkinson's Disease Centre, Nuffield, Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, UK., Laansma M; Amsterdam UMC, Dept. Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Lawrence KE; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Lochner C; SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa., Mackay C; Oxford Parkinson's Disease Centre, Nuffield, Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, UK., McMillan CT; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Melzer TR; Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.; New Zealand Brain Research Institute, Christchurch, New Zealand.; Te Kura Mahi ā- Hirikapo | School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand., Nabulsi L; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Newman B; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA., Opriessnig P; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria., Parkes LM; Division of Psychology, Communication & Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance & University of Manchester, Manchester, UK., Pellicano C; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Piras F; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Piras F; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Pirpamer L; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria., Pitcher TL; Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand.; New Zealand Brain Research Institute, Christchurch, New Zealand., Poston KL; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA., Roos A; SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Silva LS; Department of Neurology, University of Campinas-UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria., Schwingenschuh P; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria., Shahid-Besanti M; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA., Spalletta G; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Stein DJ; SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Tosun D; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA., Tsai CC; Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan, ROC.; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan City, Taiwan, ROC., van den Heuvel OA; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA.; Amsterdam UMC, Dept. Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam UMC, Department of Psychiatry, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van Heese E; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA.; Amsterdam UMC, Dept. Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Vecchio D; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Villalón-Reina JE; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Vriend C; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA.; Amsterdam UMC, Department of Psychiatry, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Brain Imaging program, Amsterdam, The Netherlands., Wang JJ; Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung, Taiwan, ROC.; Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan, ROC.; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan City, Taiwan, ROC.; Department of Chemical Engineering, Ming-Chi University of Technology, New Taipei City, Taiwan, ROC., Wu YR; Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan, ROC.; Department of Neurology, College of Medicine, Chang Gung University, Taoyuan City, Taiwan, ROC., Yasuda CL; Department of Neurology, University of Campinas-UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., van der Werf Y; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, USA.; Amsterdam UMC, Dept. Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Aug 11; Vol. 10 (1), pp. 151. Date of Electronic Publication: 2024 Aug 11.
DOI: 10.1038/s41531-024-00758-3
Abstrakt: The progression of Parkinson's disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due to the use of heterogeneous methods in small studies. Here we performed a large diffusion MRI study in PD, integrating data from 17 cohorts worldwide, to identify stage-specific profiles of white matter differences. Diffusion-weighted MRI data from 1654 participants diagnosed with PD (age: 20-89 years; 33% female) and 885 controls (age: 19-84 years; 47% female) were analyzed using the ENIGMA-DTI protocol to evaluate white matter microstructure. Skeletonized maps of fractional anisotropy (FA) and mean diffusivity (MD) were compared across Hoehn and Yahr (HY) disease groups and controls to reveal the profile of white matter alterations at different stages. We found an enhanced, more widespread pattern of microstructural alterations with each stage of PD, with eventually lower FA and higher MD in almost all regions of interest: Cohen's d effect sizes reached d = -1.01 for FA differences in the fornix at PD HY Stage 4/5. The early PD signature in HY stage 1 included higher FA and lower MD across the entire white matter skeleton, in a direction opposite to that typical of other neurodegenerative diseases. FA and MD were associated with motor and non-motor clinical dysfunction. While overridden by degenerative changes in the later stages of PD, early PD is associated with paradoxically higher FA and lower MD in PD, consistent with early compensatory changes associated with the disorder.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: