Role of subpulmonary right ventricle in sudden cardiac death in adults with congenital heart disease.

Autor:	Kawada S; Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network Toronto, and University of Toronto, Toronto, Ontario, Canada., Chakraborty P; Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network Toronto, and University of Toronto, Toronto, Ontario, Canada., Kakarla J; Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network Toronto, and University of Toronto, Toronto, Ontario, Canada., Nanthakumar J; Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network Toronto, and University of Toronto, Toronto, Ontario, Canada; Michael De Groote School of Medicine, McMaster University, Hamilton, Ontario, Canada., Mondésert B; Adult Congenital Heart Disease Centre, Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada., Khairy P; Adult Congenital Heart Disease Centre, Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada., Nair K; Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network Toronto, and University of Toronto, Toronto, Ontario, Canada. Electronic address: Krishnakumar.Nair@uhn.ca.
Jazyk:	angličtina
Zdroj:	Heart rhythm [Heart Rhythm] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.
DOI:	10.1016/j.hrthm.2024.08.016
Abstrakt:	Despite improved childhood survival of congenital heart disease (CHD) as a result of advances in management, late-onset sudden cardiac death (SCD) from malignant ventricular arrhythmias remains a leading cause of mortality in adults with CHD. Preventing SCD in these patients requires an understanding of the underlying pathophysiological mechanisms. Many CHD patients experience significant hemodynamic stress on the subpulmonary right ventricle (RV), leading to pathologic remodeling. Unlike acquired heart disease in which left ventricular pathology is prevalent, RV pathologies are crucial in the SCD pathogenesis in CHD patients. This review examines the mechanisms and management of SCD related to subpulmonary RV pathologies in CHD patients. Competing Interests: Disclosures Dr Khairy is supported by the André Chagnon Research Chair in Electrophysiology and Congenital Heart Disease. Other authors have no conflicts of interest to disclose. (Copyright © 2024 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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