| Autor: |
Carvalho RL; Postgraduate Program in Biomedical Engineering, Anhembi Morumbi University, Technological Innovation Park, São José dos Campos 12247-016, SP, Brazil., Brito TRP; Faculty of Nutrition, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil., Amaral JB; ENT Research Laboratory, Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, SP, Brazil., Monteiro FR; Postgraduate Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, SP, Brazil., Lima DB; Faculty of Nutrition, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil., Pereira TAM; Faculty of Nutrition, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil., da Costa BF; Faculty of Pharmacy, Campus Interlagos, Santo Amaro University, São Paulo 04829-300, SP, Brazil., Furtado GE; Polytechnic University of Coimbra, Rua da Misericórdia, Lagar dos Cortiços, S. Martinho do Bispo, 3045-093 Coimbra, Portugal.; SPRINT-Sport Physical Activity and Health Research & Innovation Center, Polytechnic Institute of Coimbra, 3030-329 Coimbra, Portugal.; Research Centre for Natural Resources Environment and Society (CERNAS), Polytechnic Institute of Coimbra, Bencanta, 3045-601 Coimbra, Portugal., Rodrigues PMM; Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São Paulo 12245-520, SP, Brazil., Dos Santos CAF; Postgraduate Program in Translational Medicine, Department of Medicine, Paulista School of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, SP, Brazil.; Discipline of Geriatrics and Gerontology, Department of Medicine, Paulista School of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo 04020-050, SP, Brazil., Bachi ALL; Postgraduate Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, SP, Brazil., Sarmento AO; Postgraduate Program in Biomedical Engineering, Anhembi Morumbi University, Technological Innovation Park, São José dos Campos 12247-016, SP, Brazil. |
| Abstrakt: |
Both cardiometabolic and chronic inflammatory diseases pose a significant challenge to global public health, particularly among older adults. Here, we investigated the interplay between systemic inflammatory status and the cardiometabolic index (CMI) in older men with adequate weight or obesity. In this observational cross-sectional study, older men (71.79 ± 7.35 years) were separated into groups with normal weight (NW, n = 34) and obesity (O, n = 32) to assess circulating levels of pro- and anti-inflammatory cytokines and CMI. Overall, the O group showed not only a higher inflammatory status but also increased CMI ( p < 0.0001) compared with the NW group. Interestingly, only positive correlations were found between pro- and anti-inflammatory cytokines in both groups. Through multivariate regression analysis, IL-6 (β = -0.2276, p = 0.0003) and IL-10 (β = 0.2023, p = 0.0030) significantly influenced CMI in the NW group. No significant results were found in the O group. Our findings reinforce the effects of obesity in inflammaging, as well as suggesting that the influence of cytokines in CMI occurs in older men with normal weight, since the elevated pro-inflammatory profile observed in older men with obesity can interfere in this effect. |
