The first evidence of Asian-like CPV-2b in Slovakia in a vaccinated dog with an acute fatal course of parvovirus infection: a case report.

Autor: Pelegrinová A; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Petroušková P; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia. patricia.petrouskova@uvlf.sk., Korytár Ľ; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Ondrejková A; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Drážovská M; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Vojtek B; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Mojžišová J; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Prokeš M; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Kostičák M; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Zákutná Ľ; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Dolník M; Clinic of Ruminants, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia., Mandelík R; Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Košice, 041 81, Slovakia. rene.mandelik@uvlf.sk.
Jazyk: angličtina
Zdroj: Veterinary research communications [Vet Res Commun] 2024 Oct; Vol. 48 (5), pp. 3253-3262. Date of Electronic Publication: 2024 Aug 09.
DOI: 10.1007/s11259-024-10492-z
Abstrakt: This study provides a comprehensive description of the clinical course of a fatal parvovirus infection in a vaccinated dachshund puppy, along with the first identification of a new CPV-2 variant in Slovakia, elucidated through molecular amino acid analysis of the VP2 gene. The dog exhibited clinical signs such as apathy, vomiting, and bloody diarrhea. After confirming CPV-2 infection with a commercial snap test, intensive therapy was initiated. The dog succumbed within 48 h of admission. A rectal swab sample was collected, CPV-2 was examined using the PCR method, and sequenced. The virus detected in the patient was related to strains of CPV-2c of Asian origin and unrelated to European CPV-2b strains. The sequence had genetic signatures typical of Asian strains (VP2: 5Gly, 267Tyr, 324Ile, 370Arg, and 440Thr). Phylogenetic analysis classified this strain as similar to Asian strains of CPV-2c. It is believed to be derived from an Asian strain similar to CPV-2c that acquired the 426Asp mutation. With this finding, we present the first evidence of an Asian-like CPV-2b strain in the territory of Slovakia.
(© 2024. The Author(s).)
Databáze: MEDLINE
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