Weakness Status is Differentially Associated with Time to Diabetes in Americans.

Autor:	Knoll K; Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND 58108, USA.; Healthy Aging North Dakota, North Dakota State University, Fargo, ND 58102, USA., Rhee Y; Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND 58108, USA., Fillmore N; Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58108, USA., Jurivich DA; Department of Geriatrics, University of North Dakota, Grand Forks, ND 58202, USA., Lang JJ; Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, ON K1A 0K9, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia., McGrath BM; OCHIN Inc., Portland, OR 97228, USA., Tomkinson GR; Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia., McGrath R; Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND 58108, USA.; Healthy Aging North Dakota, North Dakota State University, Fargo, ND 58102, USA.; Department of Geriatrics, University of North Dakota, Grand Forks, ND 58202, USA.; Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia.; Fargo VA Healthcare System, Fargo, ND 58102, USA.
Jazyk:	angličtina
Zdroj:	Advances in geriatric medicine and research [Adv Geriatr Med Res] 2024; Vol. 6 (3). Date of Electronic Publication: 2024 Jul 24.
DOI:	10.20900/agmr20240004
Abstrakt:	Background: The purpose of this study was to evaluate the associations of (1) individual absolute and body size normalized weakness cut-points, and (2) the collective weakness classifications on time to diabetes in Americans. Methods: We analyzed data from 9577 adults aged at least 50-years from the Health and Retirement Study. Diabetes diagnosis was self-reported. A handgrip dynamometer measured handgrip strength (HGS). Males with HGS <35.5 kg (absolute), <0.45 kg/kg (normalized to body weight), or <1.05 kg/kg/m 2 (normalized to BMI) were categorized as weak. Females were classified as weak if their HGS was <20.0 kg, <0.337 kg/kg, or <0.79 kg/kg/m 2 . Compounding weakness included falling below 1, 2, or all 3 cut-points. Results: Persons below the body weight normalized weakness cut-points had a 1.29 (95% confidence interval (CI): 1.15-1.47) higher hazard for incident diabetes, while those below the BMI normalized cut-points had a 1.30 (CI: 1.13-1.51) higher hazard. The association between absolute weakness and incident diabetes was insignificant (hazard ratio: 1.06; CI: 0.91-1.24). Americans below 1, 2, or all 3 collective weakness categories had a 1.28 (CI: 1.10-1.50), 1.29 (CI: 1.08-1.52), and 1.33 (CI: 1.09-1.63) higher hazard for the incidence of diabetes, respectively. Conclusions: Our findings indicate that while absolute weakness, which is confounded by body size, was not associated with time to diabetes, adjusting for the influence of body size by normalizing HGS to body weight and BMI was significantly associated with time to diabetes. This suggests that muscle strength, not body size, may be driving such associations with time to diabetes. Competing Interests: CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.
Databáze:	MEDLINE
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