The effect of acute social isolation on neural molecular responses in components of the social decision-making network.

Autor: Lopes PC; Schmid College of Science and Technology, Chapman University, Orange, CA, USA. lopes@chapman.edu., Chang M; Schmid College of Science and Technology, Chapman University, Orange, CA, USA., Holloway F; Schmid College of Science and Technology, Chapman University, Orange, CA, USA., Fatusin B; Schmid College of Science and Technology, Chapman University, Orange, CA, USA., Patel S; Schmid College of Science and Technology, Chapman University, Orange, CA, USA., Siemonsma C; Schmid College of Science and Technology, Chapman University, Orange, CA, USA., Kindel M; Schmid College of Science and Technology, Chapman University, Orange, CA, USA.; Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.
Jazyk: angličtina
Zdroj: BMC genomics [BMC Genomics] 2024 Aug 08; Vol. 25 (1), pp. 771. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1186/s12864-024-10653-z
Abstrakt: Prolonged or chronic social isolation has pronounced effects on animals, ranging from altered stress responses, increased anxiety and aggressive behaviour, and even increased mortality. The effects of shorter periods of isolation are much less well researched; however, short periods of isolation are used routinely for testing animal behaviour and physiology. Here, we studied how a 3 h period of isolation from a cagemate affected neural gene expression in three brain regions that contain important components of the social decision-making network, the hypothalamus, the nucleus taeniae of the amygdala, and the bed nucleus of the stria terminalis, using a gregarious bird as a model (zebra finches). We found evidence suggestive of altered neural activity, synaptic transmission, metabolism, and even potentially pain perception, all of which could create cofounding effects on experimental tests that involve isolating animals. We recommend that the effects of short-term social isolation need to be better understood and propose alternatives to isolating animals for testing.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje