Associations between exposure to extreme ambient heat and neural tube defects in Georgia, USA: A population-based case-control study.

Autor: LaPointe S; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Beagle LE; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Zheng X; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Kancherla V; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Mutic A; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA., Chang HH; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Gaskins AJ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address: audrey.jane.gaskins@emory.edu.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Nov 15; Vol. 261, pp. 119756. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1016/j.envres.2024.119756
Abstrakt: Introduction: The association between extreme ambient heat exposures during pregnancy and neural tube defects (NTDs) in offspring remains unclear. This study sought to estimate the association between exposure to extreme ambient heat during periconception and NTDs.
Methods: This population-based case-control study in Georgia, USA (1994-2017) included 825 isolated NTD cases (473 anencephaly, 352 spina bifida) and 3,300 controls matched 1:4 on county of residence and time period of delivery. Daily ambient temperature data were linked to fetal death and birth records by county of residence. Extreme ambient heat exposure was defined as the number of consecutive days the daily apparent temperature exceeded the county-specific 95th percentile (derived over 1980-2010) during an eight-week periconception period. We calculated adjusted odds ratios (aORs) and 95% confidence intervals (CI) using conditional logistic regression models adjusted for maternal age, education, and ethnicity and month and year of last menstrual period.
Results: The aORs for NTDs were 1.09 (95% CI 1.01, 1.17), 1.18 (95% CI 1.03, 1.36), and 1.29 (95% CI 1.04, 1.58) for exposure to 1-2, 3-5, and 6 or more consecutive days with apparent ambient temperatures exceeding the county-specific 95th percentile during periconception, respectively, compared to no days of extreme ambient heat exposure. Weekly analysis of extreme heat exposure indicated consistently elevated odds of offspring NTDs during periconception. These results were largely driven by spina bifida cases.
Conclusions: Our results highlight potential health threats posed by increasing global average temperatures for pregnant people with implications for increased risk of neural tube defects in their offspring.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Howard H. Chang reports financial support was provided by National Institute of Environmental Health Sciences. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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