Small molecule and big function: MicroRNA-mediated apoptosis in rheumatoid arthritis.

Autor: Saadh MJ; Faculty of Pharmacy, Middle East University, Amman 11831, Jordan. Electronic address: msaadeh@meu.edu.jo., Ahmed HH; Department of Pharmacy, Al-Noor University College, Nineveh, Iraq. Electronic address: hanan.hasan@alnoor.edu.iq., Singh A; Department of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bengaluru, Karnataka 560069, India; Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan 303012, India., Mustafa MA; School of Pharmacy-Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Uttar Pradesh-247341, India; Department of Pharmacy, Arka Jain University, Jamshedpur, Jharkhand- 831001, India. Electronic address: Mohammed.ahmed.mustafa@sadiq.edu.iq., Al Zuhairi RAH; National University of Science and Technology, Dhi Qar, Iraq., Ghildiyal P; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India. Electronic address: pallavighildiyal@uumail.in., Jawad MJ; Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq. Electronic address: mahmood@g.alzahu.edu.iq., Alsaikhan F; College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia; School of Pharmacy, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia. Electronic address: fahadalsaikhan8@gmail.com., Khalilollah S; Department of Neurosurgery, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Akhavan-Sigari R; Department of Neurosurgery, University Medical Center Tuebingen, Germany; Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, Poland.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 Sep; Vol. 261, pp. 155508. Date of Electronic Publication: 2024 Jul 30.
DOI: 10.1016/j.prp.2024.155508
Abstrakt: Rheumatoid arthritis (RA) is a common autoimmune condition and chronic inflammatory disease, mostly affecting synovial joints. The complex pathogenesis of RA is supportive of high morbidity, disability, and mortality rates. Pathological changes a common characteristic in RA synovial tissue is attributed to the inadequacy of apoptotic pathways. In that regard, apoptotic pathways have been the center of attention in RA therapeutic approaches. As the regulators in the complex network of apoptosis, microRNAs (miRNAs) are found to be vital modulators in both intrinsic and extrinsic pathways through altering their regulatory genes. Indeed, miRNA, a member of the family of non-coding RNAs, are found to be an important player in not even apoptosis, but proliferation, gene expression, signaling pathways, and angiogenesis. Aberrant expression of miRNAs is implicated in attenuation and/or intensification of various apoptosis routes, resulting in culmination of human diseases including RA. Considering the need for more studies focused on the underlying mechanisms of RA in order to elevate the unsatisfactory clinical treatments, this study is aimed to delineate the importance of apoptosis in the pathophysiology of this disease. As well, this review is focused on the critical role of miRNAs in inducing or inhibiting apoptosis of RA-synovial fibroblasts and fibroblast-like synoviocytes and how this mechanism can be exerted for therapeutic purposes for RA.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Fahad Alsaikhan reports financial support was provided by Prince Sattam bin Abdulaziz University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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