Wirelessly Actuated Microfluidic Pump and Valve for Controlled Liquid Delivery in Dental Implants.

Autor: Xu Y; Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37212, USA.; Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville, TN, 37212, USA., Lin H; Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37212, USA., Xiao B; Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37212, USA.; Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville, TN, 37212, USA., Tanoto H; Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77840, USA., Berinstein J; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, 37212, USA., Khoshnaw A; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, 37212, USA., Young S; Katz Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, 77054, USA., Zhou Y; Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77840, USA., Dong X; Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37212, USA.; Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville, TN, 37212, USA.; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Aug 07, pp. e2402373. Date of Electronic Publication: 2024 Aug 07.
DOI: 10.1002/adhm.202402373
Abstrakt: Enabling minimally invasive and precise control of liquid release in dental implants is crucial for therapeutic functions such as delivering antibiotics to prevent biofilm formation, infusing stem cells to promote osseointegration, and administering other biomedicines. However, achieving controllable liquid cargo release in dental implants remains challenging due to the lack of wireless and miniaturized fluidic control mechanisms. Here wireless miniature pumps and valves that allow remote activation of liquid cargo delivery in dental implants, actuated and controlled by external magnetic fields (<65 mT), are reported. A magnet-screw mechanism in a fluidic channel to function as a piston pump, alongside a flexible magnetic valve designed to open and close the fluidic channel, is proposed. The mechanisms are showcased by storing and releasing of liquid up to 52 µL in a dental implant. The liquid cargos are delivered directly to the implant-bone interface, a region traditionally difficult to access. On-demand liquid delivery is further showed by a metal implant inside both dental phantoms and porcine jawbones. The mechanisms are promising for controllable liquid release after implant placement with minimal invasion, paving the way for implantable devices that enable long-term and targeted delivery of therapeutic agents in various bioengineering applications.
(© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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