HIV-1 interaction with an O -glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralizing antibodies.

Autor:	Heindel DW; Divison of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Figueroa Acosta DM; Divison of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goff M; Divison of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yengo CK; Divison of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jan M; Divison of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Liu X; Divison of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang XH; VA New York Harbor Healthcare System-Manhattan, New York, NY, USA., Petrova MI; Department of Bioscience Engineering, University of Antwerp, Antwerp, Belgium., Zhang M; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Sagar M; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Virology, Immunology and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Barnette P; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Pandey S; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Hessell AJ; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA., Chan KW; Department of Biochemistry and Molecular Pharmacology New York University Grossman School of Medicine, New York, NY, USA., Kong XP; Department of Biochemistry and Molecular Pharmacology New York University Grossman School of Medicine, New York, NY, USA., Chen BK; Divison of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mahal LK; Department of Chemistry, University of Alberta, Edmonton, AB, Canada., Bensing BA; Department of Medicine, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, CA, USA., Hioe CE; Divison of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; James J. Peters VA Medical Center, Bronx, NY, USA.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Jun 27; Vol. 27 (8), pp. 110390. Date of Electronic Publication: 2024 Jun 27 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.110390
Abstrakt:	Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is associated with an increased risk of HIV-1 transmission. However, HIV-1 may also bind bacteria or bacterial products to impact infectivity and transmissibility. This study evaluated HIV-1 interactions with bacteria through glycan-binding lectins. The Streptococcal Siglec-like lectin SLBR-N, a part of the fimbriae shrouding the bacteria surface that recognizes α2,3 sialyated O -linked glycans, was noted for its ability to enhance HIV-1 infectivity in the context of cell-free infection and cell-to-cell transfer. Enhancing effects were recapitulated with O -glycan-binding plant lectins, signifying the importance of O -glycans. N -glycan-binding bacterial lectins FimH and Msl had no effect. SLBR-N was demonstrated to capture and transfer infectious HIV-1 virions, bind to O -glycans on HIV-1 Env, and increase HIV-1 resistance to neutralizing antibodies targeting different regions of Env. This study highlights the potential contribution of O -glycan-binding lectins from commensal bacteria at the mucosa in promoting HIV-1 infection. Competing Interests: The authors declare no competing interests, except for M.I.P. who is currently employed by Winclove Probiotics and serves as a consultant for academic and industrial representatives in the field of microbiome and probiotics. Her consultancy clients had no role in drafting this manuscript or the decision to submit the work for publication.
Databáze:	MEDLINE
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