Calcium Pyrophosphate Crystal Deposition: Insights to Risks Factors and Associated Conditions.

Autor: Parperis K; Department of Medicine, Division of Rheumatology University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA. parperis.konstantinos-marinos@ucy.ac.cy.; University of Cyprus Medical School, Nicosia, Cyprus. parperis.konstantinos-marinos@ucy.ac.cy., Constantinou A; University of Cyprus Medical School, Nicosia, Cyprus.
Jazyk: angličtina
Zdroj: Current rheumatology reports [Curr Rheumatol Rep] 2024 Nov; Vol. 26 (11), pp. 375-382. Date of Electronic Publication: 2024 Aug 05.
DOI: 10.1007/s11926-024-01158-5
Abstrakt: Purpose of the Review: This review provides an overview of medical conditions and risk factors associated with CPPD.
Recent Findings: Recent studies have indicated that CPPD patients may have a higher risk for systemic conditions such as cardiovascular diseases. Calcium pyrophosphate deposition disease (CPPD) is a common crystal arthropathy that primarily affects older adults, and, in most cases, the aetiology is idiopathic. Age is the most remarkable risk factor and due to the aging population, the prevalence of this condition is expected to increase. Strong evidence supports an association between CPPD and several metabolic and endocrine conditions, including hemochromatosis, hyperparathyroidism, hypomagnesemia, and hypophosphatasia. Additionally, there is growing evidence of an increased risk for cardiovascular diseases among CPPD patients, alongside potential links to rheumatic disorders, gender, medications, and joint trauma. Further research is needed to explore the underlying mechanisms linking CPPD to associated conditions and to develop targeted therapies with the aim of improving patient outcomes.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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