Enteroviral meningitis in children: Clinical and laboratory features with and without pleocytosis.

Autor:	Şen ZS; Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus, Ankara, Turkey., Ozdem S; Pediatric Infectious Disease, Mersin Şehir Eğitim ve Araştırma Hastanesi, Mersin, Turkey., Yalcinkaya R; Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus, Ankara, Turkey., Gumuser Cinni R; Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus, Ankara, Turkey., Polat E; Pediatrics, Dr Sami Ulus Gynecology Obstetrics and Child Health and Diseases Training and Research Hospital, Çankaya, Turkey., Polat M; Pediatric Infectious Disease, Gazi University Faculty of Medicine, Ankara, Turkey., Kaman A; Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus, Ankara, Turkey., Aydın Teke T; Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus, Ankara, Turkey., Tanir G; Pediatric Infectious Disease, SBU Ankara Dr Sami Ulus Maternity Child Health and Diseases Training and Research Hospital, Ankara, Turkey., Öz FN; Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	Klinische Padiatrie [Klin Padiatr] 2024 Aug 02. Date of Electronic Publication: 2024 Aug 02.
DOI:	10.1055/a-2345-3186
Abstrakt:	Background: Enteroviruses (EV) are most common causes of the etiologically known aseptic meningitis in children. EV can be detected with polymerase chain reaction (PCR) in cerebrospinal fluid (CSF) samples. We aimed to evaluate the clinical and laboratory characteristics of children diagnosed with PCR-confirmed EV meningitis in CSF samples. Patients: Patients aged 1 month to 17 years who underwent lumbar puncture (LP) with suspected meningitis and had CSF viral PCR and culture results between September 2012 and January 2021 at a tertiary care hospital in Turkey were included. Methods: Patients with no virus detected in CSF samples by PCR was comprised PCR-negative group. The EV PCR-positive patients were divided into two groups based on CSF pleocytosis as enteroviral meningitis (EVM) with CSF pleocytosis and EVM without CSF pleocytosis, and compared in terms of clinical and laboratory features. Results: 78 (38.2%) were EV PCR-positive, and 126 (61.8%) were PCR-negative. Pleocytosis was detected in 55 (70.5%) EV PCR-positive patients and 94 (74.6%) of PCR-negative patients. Convulsion was significantly frequent (p=0.017) in EV PCR-positive patients with no pleocytosis. Protein and lactate concentrations in CSF were significantly higher in EV PCR-positive patients with pleocytosis (p=0.048, p=0.001, respectively). Median hospital stay was significantly longer in PCR-negative group (p<0.001). Conclusion: Diagnosing EVM with PCR prevents long-term hospitalization, unnecessary antibiotic use and healthcare-related complications. Competing Interests: The authors declare that they have no conflict of interest. (Thieme. All rights reserved.)
Databáze:	MEDLINE
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