Correction for partial volume averaging in the quantification of radiopaque nanomaterial-embedded resorbable polymers.

Autor:	Melancon AD; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States of America.; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, 77030, United States of America., Jacobsen M; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, 77030, United States of America.; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States of America., Damasco J; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States of America., Perez J; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States of America., Bernardino M; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States of America., Valentin ES; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States of America., Court KA; Department of Nanomedicine, Houston Methodist Research Hospital, Houston, TX, 77030, United States of America., Godin B; Department of Nanomedicine, Houston Methodist Research Hospital, Houston, TX, 77030, United States of America., Layman R; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, 77030, United States of America.; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States of America., Melancon MP; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, 77030, United States of America.; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States of America.
Jazyk:	angličtina
Zdroj:	Biomedical physics & engineering express [Biomed Phys Eng Express] 2024 Aug 12; Vol. 10 (5). Date of Electronic Publication: 2024 Aug 12.
DOI:	10.1088/2057-1976/ad6a66
Abstrakt:	Resorbable inferior vena cava (IVC) filters require embedded contrast for image-guided placement and integrity monitoring. We calculated correction factors to account for partial volume averaging of thin nanoparticle (NP)-embedded materials, accounting for object and slice thicknesses, background signal, and nanoparticle concentration. We used phantoms containing polycaprolactone disks embedded with bismuth (Bi) or ytterbium (Yb): 0.4- to 1.2-mm-thick disks of 20 mg ml -1 NPs (thickness phantom), 0.4-mm-thick disks of 0-20 mg ml -1 NPs in 2 mg ml -1 iodine (concentration phantom), and 20 mg ml -1 NPs in 0.4-mm-thick disks in 0-10 mg ml -1 iodine (background phantom). Phantoms were scanned on a dual-source CT with 80, 90, 100, and 150 kVp with tin filtration and reconstructed at 1.0- to 1.5-mm slice thickness with a 0.1-mm interval. Following scanning, disks were processed for inductively coupled plasma optical emission spectrometry (ICP-OES) to determine NP concentration. Mean and maximum CT numbers (HU) of all disks were measured over a 0.5-cm 2 area for each kVp. HU was converted to concentration using previously measured calibrations. Concentration measurements were corrected for partial volume averaging by subtracting residual slice background and extrapolating disk thickness to both nominal and measured slice sensitivity profiles (SSP, mm). Slice thickness to agreement (STTA, mm) was calculated by replacing the CT-derived concentrations with ICP-OES measurements and solving for thickness. Slice thickness correction factors improved agreement with ICP-OES for all measured data. Yb corrections resulted in lower STTA than Bi corrections in the concentration phantom (1.01 versus 1.31 STTA/SSP, where 1.0 is perfect agreement), phantoms with varying thickness (1.30 versus 1.87 STTA/SSP), and similar ratio in phantoms with varying background iodine concentration (1.34 versus 1.35 STTA/SSP). All measured concentrations correlated strongly with ICP-OES and all corrections for partial volume averaging increased agreement with ICP-OES concentration, demonstrating potential for monitoring the integrity of thin IVC resorbable filters with CT. (Creative Commons Attribution license.)
Databáze:	MEDLINE
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