Quantitative Assessment of Intervertebral Disc Degeneration Using the Disc Signal Intensity Index in Patients With Spine-Related Pain.

Autor:	Tsuchiya K; Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, JPN., Okano I; Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, JPN., Kobayashi R; Department of Anesthesiology, Showa University School of Medicine, Tokyo, JPN., Dodo Y; Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, JPN., Ogawa J; Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, JPN., Hara E; Department of Anesthesiology, Showa University School of Medicine, Tokyo, JPN., Taketomi A; Department of Anesthesiology, Showa University School of Medicine, Tokyo, JPN., Kudo Y; Department of Orthopedic Surgery, Showa University School of Medicine, Tokyo, JPN.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 01; Vol. 16 (7), pp. e63553. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024).
DOI:	10.7759/cureus.63553
Abstrakt:	Objective This is a retrospective observational study that aims to investigate the association between disc signal intensity index (DSI2) scores and patient-reported outcome measures in patients with lumbar spine disorders. Methods We introduced DSI2 to quantitatively assess disc degeneration. MRI records of patients with lumbar spine-related pain between 2019 and 2022 were analyzed retrospectively. Patient demographics and outcomes were collected, including the Numerical Rating Scale of Pain and EuroQol Group 5 Dimension 5-Level Quality of Life (EQ-5D-5L) scores. The DSI2 was calculated by dividing the mean signal intensity of the L1-S1 discs by that of the CSF on midsagittal T2-weighted MRI images. Results Each DSI2 level corresponded to a Pfirrmann grade score at the respective lumbar level. Multivariable linear regression analysis using the EQ-5D-5L as the objective variable identified BMI (p = 0.007) and average DSI2 (p = 0.018) as independent risk factors for EQ-5D-5L deterioration. However, the mean Pfirrmann grade score was not an independent risk factor (p = 0.58). Conclusion Our study using DSI2 showed the relationship between disc degeneration and EQ-5D-5L deterioration. Distinct from the Pfirrmann grading system, the DSI2 method is a promising alternative for future disc research that excellently detects the subtle progression of degeneration. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Showa University Ethics Committee issued approval 2023-169-A. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: Koki Tsuchiya received a Showa University Research Grant for Young Researchers 2023 for his research work, including this study. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Tsuchiya et al.)
Databáze:	MEDLINE
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