Coat colour in marsupials: genetic variants at the ASIP locus determine grey and black fur of the brushtail possum.
| Autor: | Bond DM; Department of Anatomy, University of Otago, Dunedin, New Zealand., Veale A; Manaaki Whenua-Landcare Research, Lincoln, New Zealand., Alexander A; Department of Anatomy, University of Otago, Dunedin, New Zealand., Hore TA; Department of Anatomy, University of Otago, Dunedin, New Zealand. |
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| Jazyk: | angličtina |
| Zdroj: | Royal Society open science [R Soc Open Sci] 2024 Jul 31; Vol. 11 (7), pp. 240806. Date of Electronic Publication: 2024 Jul 31 (Print Publication: 2024). |
| DOI: | 10.1098/rsos.240806 |
| Abstrakt: | The possession of fur or hair is a defining characteristic of mammals and can occur in a variety of colours and patterns. While genetic determinants of coat colour are well described in eutherian 'placental' mammals, the other major mammalian infraclass, marsupials, is grossly understudied. The fur of the common brushtail possum ( Trichosurus vulpecula ), an iconic native mammal found throughout Australia and introduced into Aotearoa New Zealand, possesses two main colour morphs: grey and black. To identify genetic variants associated with coat colour, we performed a genome-wide association study (GWAS) with genotype by sequencing (GBS) data. Single nucleotide variants (SNVs) on chromosome 3, close to the agouti signalling protein ( ASIP ) gene that controls the temporal and spatial distribution of pigments in eutherian mammals, were identified. Fine-mapping identified a C>T variant at chr3:100483705 that results in a ASIP:p.Arg115Cys missense substitution, and animals homozygous for this variant have black fur. In addition to uncovering the first genetic determinant of coat colour in a natural marsupial population, comparative analysis of ASIP in divergent marsupial species identified the dasyurids as having accelerated evolution, reflecting their well described diversity of coat colour and pattern. Competing Interests: All authors declare that there are no competing financial interests. T.A.H. and D.M.B. are directors and shareholders of TOTOGEN Ltd, an agricultural genetics consultancy. (© 2024 The Authors.) |
| Databáze: | MEDLINE |
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