Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.

Autor: Leyte-Vidal A; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, 33101, USA., DeFilippis R; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Outhwaite IR; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Kwan I; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA.; Department of Biochemistry and Cell Biology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Lee JY; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA., Leavitt C; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Miller KB; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Rea D; Adult Hematology Department, Hôpital Saint-Louis, Paris, France., Rangwala AM; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Lou K; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, 94158, USA.; Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA., Patel S; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Alvarez A; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA., Shokat KM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, 94158, USA.; Howard Hughes Medical Institute, University of California, San Francisco, CA, 94158, USA.; Department of Chemistry, University of California, Berkeley, CA, 94720, USA., Bahar I; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA.; Department of Biochemistry and Cell Biology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA., Seeliger MA; Department of Pharmacological Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA., Shah NP; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA. neil.shah@ucsf.edu.
Jazyk: angličtina
Zdroj: Leukemia [Leukemia] 2024 Sep; Vol. 38 (9), pp. 2046-2050. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1038/s41375-024-02353-0
Databáze: MEDLINE