Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.

Autor: Liu YC; Medical College, Guangxi University, Nanning, Guangxi, China., Li RC; Medical College, Guangxi University, Nanning, Guangxi, China., Wang WK; Medical College, Guangxi University, Nanning, Guangxi, China., Chen YZ; Medical College, Guangxi University, Nanning, Guangxi, China., He QK; Medical College, Guangxi University, Nanning, Guangxi, China., Xu ZR; Translational Medicine Research Center, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China., Yang YF; Medical College, Guangxi University, Nanning, Guangxi, China., Cheng SY; Medical College, Guangxi University, Nanning, Guangxi, China., Wang HL; Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China., Qi ZQ; Medical College, Guangxi University, Nanning, Guangxi, China., Xu CL; Reproductive Medical Center of Nanning Second People's Hospital, Nanning, Guangxi, China., Liu Y; Medical College, Guangxi University, Nanning, Guangxi, China.
Jazyk: angličtina
Zdroj: Environmental toxicology [Environ Toxicol] 2024 Nov; Vol. 39 (11), pp. 5074-5085. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1002/tox.24390
Abstrakt: Acrylamide (AAM), a compound extensively utilized in various industrial applications, has been reported to induce toxic effects across multiple tissues in living organisms. Despite its widespread use, the impact of AAM on ovarian function and the mechanisms underlying these effects remain poorly understood. Here, we established an AAM-exposed mouse toxicological model using 21 days of intragastric AAM administration. AAM exposure decreased ovarian coefficient and impaired follicle development. Further investigations revealed AAM would trigger apoptosis and disturb tricarboxylic acid cycle in ovarian tissue, thus affecting mitochondrial electron transport function. Moreover, AAM exposure decreased oocyte and embryo development potential, mechanically associated with pericentrin and phosphorylated Aurora A cluster failure, leading to meiotic spindle assembly defects. Collectively, these results suggest that AAM exposure may lead to apoptosis, glucose metabolic disorders, and mitochondrial dysfunction in ovary tissue, ultimately compromising oocyte quality.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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