Performance of the Risk Scores for Predicting In-Hospital Mortality in Patients with Acute Coronary Syndrome in a Chinese Cohort.

Autor:	Bai L; Department of Cardiology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China., Li YM; Department of Cardiology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China., Yang BS; Department of Cardiology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China., Cheng YH; Department of Cardiology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China., Zhang YK; Department of Cardiology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China., Liao GZ; Department of Cardiology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China., Ye YY; Department of Cardiology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China., Chen XF; Department of Cardiology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China., Chai H; Department of Academic Affairs, West China School of Medicine/West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China., Peng Y; Department of Cardiology, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China.
Jazyk:	angličtina
Zdroj:	Reviews in cardiovascular medicine [Rev Cardiovasc Med] 2023 Dec 19; Vol. 24 (12), pp. 356. Date of Electronic Publication: 2023 Dec 19 (Print Publication: 2023).
DOI:	10.31083/j.rcm2412356
Abstrakt:	Background: The prognosis of patients with acute coronary syndrome (ACS) varies greatly, and risk assessment models can help clinicians to identify and manage high-risk patients. While the Global Registry of Acute Coronary Events (GRACE) model is widely used, the clinical pathways for acute coronary syndromes (CPACS), which was constructed based on the Chinese population, and acute coronary treatment and intervention outcomes network (ACTION) have not yet been validated in the Chinese population. Methods: Patients with ACS who underwent coronary angiography or percutaneous coronary intervention from 2011 to 2020, were retrospectively recruited and the appropriate corresponding clinical indicators was obtained. The primary endpoint was in-hospital mortality. The performance of the GRACE, GRACE 2.0, ACTION, thrombolysis in myocardial infarction (TIMI) and CPACS risk models was evaluated and compared. Results: A total of 19,237 patients with ACS were included. Overall, in-hospital mortality was 2.2%. ACTION showed the highest accuracy in predicting discriminated risk (c-index 0.945, 95% confidence interval [CI] 0.922-0.955), but the calibration was not satisfactory. GRACE and GRACE 2.0 did not significantly differ in discrimination ( p = 0.1480). GRACE showed the most accurate calibration in all patients and in the subgroup analysis of all models. CPACS (c-index 0.841, 95% CI 0.821-0.861) and TIMI (c-index 0.811, 95% CI 0.787-0.835) did not outperform (c-index 0.926, 95% CI 0.911-0.940). Conclusions: In contemporary Chinese ACS patients, the ACTION risk model's calibration is not satisfactory, although outperformed the gold standard GRACE model in predicting hospital mortality. The CPACS model developed for Chinese patients did not show better predictive performance than the GRACE model. Competing Interests: The authors declare no conflict of interest. (Copyright: © 2023 The Author(s). Published by IMR Press.)
Databáze:	MEDLINE
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