The impact of subclinical psychotic symptoms on delay and effort discounting: Insights from behavioral, computational, and electrophysiological methods.

Autor: Terenzi D; Institut de Neurosciences de la Timone, UMR 7289 CNRS, Aix-Marseille Université, Marseille, France. Electronic address: damianoterenzi@gmail.com., Silvetti M; Computational and Translational Neuroscience Lab (CTNLab), Institute of Cognitive Sciences and Technologies, National Research Council (CNR), Rome, Italy., Zoccolan G; Area of Neuroscience, SISSA, Trieste, Italy., Rumiati RI; Area of Neuroscience, SISSA, Trieste, Italy; University of Rome Tor Vergata, Rome, Italy., Aiello M; Department of Psychology 'Renzo Canestrari', University of Bologna, Bologna, Italy.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2024 Sep; Vol. 271, pp. 271-280. Date of Electronic Publication: 2024 Jul 27.
DOI: 10.1016/j.schres.2024.07.044
Abstrakt: Background: The ability to value rewards is crucial for adaptive behavior and is influenced by the time and effort required to obtain them. Impairments in these computations have been observed in patients with schizophrenia and may be present in individuals with subclinical psychotic symptoms (PS).
Methods: In this study, we employed delay and effort-discounting tasks with food rewards in thirty-nine participants divided into high and low levels of PS. We investigated the underlying mechanisms of effort-discounting through computational modelling of dopamine prefrontal and subcortical circuits and the electrophysiological biomarker of both delay and effort-discounting alterations through resting-state frontal alpha asymmetry (FAA).
Results: Results revealed greater delay discounting in the High PS group compared to the Low PS group but no differences in the effort discounting task. However, in this task, the same levels of estimated dopamine release were associated with a lower willingness to exert effort for high-calorie food rewards in High PS participants compared to Low PS participants. Although there were no significant differences in FAA between the High PS and Low PS groups, FAA was significantly associated with the severity of participants' negative symptoms.
Conclusions: Our study suggests that the dysfunction in temporal and effort cost computations, seen in patients with schizophrenia, may be present in individuals with subclinical PS. These findings provide valuable insight into the early vulnerability markers (behavioral, computational, and electrophysiological) for psychosis, which may aid in the development of preventive interventions. These findings are preliminary and warrant further investigation.
Competing Interests: Declaration of competing interest The authors declare none.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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