High-order brain interactions in ketamine during rest and task: a double-blinded cross-over design using portable EEG on male participants.

Autor: Herzog R; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile. ruben.herzog@icm-institute.org.; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France. ruben.herzog@icm-institute.org., Barbey FM; Cumulus Neuroscience Ltd, Dublin, Ireland., Islam MN; Cumulus Neuroscience Ltd, Dublin, Ireland., Rueda-Delgado L; Cumulus Neuroscience Ltd, Dublin, Ireland., Nolan H; Cumulus Neuroscience Ltd, Dublin, Ireland., Prado P; Escuela de Fonoaudiología, Facultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastián, Santiago, Chile., Krylova M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Izyurov I; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Javaheripour N; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Danyeli LV; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Sen ZD; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Walter M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.; German Center for Mental Health (DZPG), partner site Halle-Jena-Magdeburg, Jena, Germany., O'Donnell P; Neuroscience Drug Discovery Unit, Takeda Pharmaceuticals, Cambridge, MA, 02390, USA., Buhl DL; Neuroscience Drug Discovery Unit, Takeda Pharmaceuticals, Cambridge, MA, 02390, USA., Murphy B; Cumulus Neuroscience Ltd, Dublin, Ireland., Ibanez A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile. agustin.ibanez@gbhi.org.; Global Brain Health Institute, UCSF and Trinity College Dublin, Dublin, Ireland. agustin.ibanez@gbhi.org.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2024 Jul 27; Vol. 14 (1), pp. 310. Date of Electronic Publication: 2024 Jul 27.
DOI: 10.1038/s41398-024-03029-0
Abstrakt: Ketamine is a dissociative anesthetic that induces a shift in global consciousness states and related brain dynamics. Portable low-density EEG systems could be used to monitor these effects. However, previous evidence is almost null and lacks adequate methods to address global dynamics with a small number of electrodes. This study delves into brain high-order interactions (HOI) to explore the effects of ketamine using portable EEG. In a double-blinded cross-over design, 30 male adults (mean age = 25.57, SD = 3.74) were administered racemic ketamine and compared against saline infusion as a control. Both task-driven (auditory oddball paradigm) and resting-state EEG were recorded. HOI were computed using advanced multivariate information theory tools, allowing us to quantify nonlinear statistical dependencies between all possible electrode combinations. Ketamine induced an increase in redundancy in brain dynamics (copies of the same information that can be retrieved from 3 or more electrodes), most significantly in the alpha frequency band. Redundancy was more evident during resting state, associated with a shift in conscious states towards more dissociative tendencies. Furthermore, in the task-driven context (auditory oddball), the impact of ketamine on redundancy was more significant for predictable (standard stimuli) compared to deviant ones. Finally, associations were observed between ketamine's HOI and experiences of derealization. Ketamine appears to increase redundancy and HOI across psychometric measures, suggesting these effects are correlated with alterations in consciousness towards dissociation. In comparisons with event-related potential (ERP) or standard functional connectivity metrics, HOI represent an innovative method to combine all signal spatial interactions obtained from low-density dry EEG in drug interventions, as it is the only approach that exploits all possible combinations between electrodes. This research emphasizes the potential of complexity measures coupled with portable EEG devices in monitoring shifts in consciousness, especially when paired with low-density configurations, paving the way for better understanding and monitoring of pharmacological-induced changes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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