| Autor: |
Foster R; Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil., Veras MM; Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil., Bachi ALL; Post-Graduation Program in Health Science, University of Santo Amaro, São Paulo 04743-030, Brazil., Amaral JBD; Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil., Yariwake VY; Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil., Waked D; Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil., Rodrigues ACB; Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil., Farrajota M; Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil., Pires RP; Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil., Pantaleão K; Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil., Dos Santos JMB; Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil., Damian FH; Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil., Saldiva PH; Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil., Vaisberg MW; Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil. |
| Abstrakt: |
Atmospheric pollution can be defined as a set of changes that occur in the composition of the air, making it unsuitable and/or harmful and thereby generating adverse effects on human health. The regular practice of physical exercise (PE) is associated with the preservation and/or improvement of health; however, it can be influenced by neuroimmunoendocrine mechanisms and external factors such as air pollution, highlighting the need for studies involving the practice of PE in polluted environments. Herein, 24 male C57BL/6 mice were evaluated, distributed into four groups (exposed to a high concentration of pollutants/sedentary, exposed to a high concentration of pollutants/exercised, exposed to ambient air/sedentary, and exposed to ambient air/exercised). The exposure to pollutants occurred in the environmental particle concentrator (CPA) and the physical training was performed on a treadmill specially designed for use within the CPA. Pro- and anti-inflammatory markers in blood and bronchoalveolar lavage (BALF), BALF cellularity, and lung tissue were evaluated. Although the active group exposed to a high concentration of pollution showed a greater inflammatory response, both the correlation analysis and the ratio between pro- and anti-inflammatory cytokines demonstrated that the exercised group presented greater anti-inflammatory activity, suggesting a protective/adaptative effect of exercise when carried out in a polluted environment. |
