The effects of corticotropin-releasing factor on motor learning.

Autor: Takeuchi E; Institute of Innovative Science and Technology, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan., Hatanaka T; Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.; Course of Pharmacy, Graduated School of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-0295, Japan., Iijima T; Institute of Innovative Science and Technology, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.; Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan., Kimura M; Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan., Katoh A; Institute of Innovative Science and Technology, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. akiraka@tokai.ac.jp.; Department of Physiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. akiraka@tokai.ac.jp.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jul 24; Vol. 14 (1), pp. 17056. Date of Electronic Publication: 2024 Jul 24.
DOI: 10.1038/s41598-024-66736-0
Abstrakt: Corticotropin-releasing factor (CRF) is mainly secreted from the hypothalamic paraventricular nuclei and plays a crucial role in stress-related responses. Recent studies have reported that CRF is a neuromodulator in the central nervous system. In the cerebellum, CRF is essential for the induction of long-term depression (LTD) at the parallel fiber-Purkinje cell synapses. Given that LTD is thought to be one of the fundamental mechanisms of motor learning, CRF may affect motor learning. However, the role of CRF in motor learning in vivo remains unclear. In this study, we aimed to examine the role of CRF in motor learning. This was achieved through a series of behavioral experiments involving the in vivo administration of CRF and its antagonists. Rats injected with CRF directly into the cerebellum exhibited superior performance on the rotarod test, especially during initial training phases, compared to control subjects. Conversely, rats receiving a CRF receptor antagonist demonstrated reduced endurance on the rotating rod compared to controls. Notably, CRF mRNA expression levels in the cerebellum did not show significant variance between the CRF-injected and control groups. These findings imply a critical role of endogenous CRF in cerebellar motor learning and suggest that exogenous CRF can augment this process. (199 words).
(© 2024. The Author(s).)
Databáze: MEDLINE
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