Communication: High-Density Lipoprotein-Specific Phospholipid Efflux in Familial Hypercholesterolemia.

Autor:	Sato M; Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-City, Tochigi, Japan.; Biochemical Research Laboratory, Eiken Chemical Co., Ltd., Shimotsuga-Gun, Tochigi, Japan., Hamasaki M; Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-City, Tochigi, Japan.; Biochemical Research Laboratory, Eiken Chemical Co., Ltd., Shimotsuga-Gun, Tochigi, Japan., Neufeld EB; Lipoprotein Metabolism Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Remaley AT; Lipoprotein Metabolism Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.; NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, USA., Kotani K; Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-City, Tochigi, Japan kazukotani@jichi.ac.jp.
Jazyk:	angličtina
Zdroj:	Annals of clinical and laboratory science [Ann Clin Lab Sci] 2024 May; Vol. 54 (3), pp. 419-422.
Abstrakt:	Objective: Familial hypercholesterolemia (FH) is characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD). Although the role of LDL-C in FH has been studied, the contribution of high-density lipoproteins (HDL) to CVD in FH remains unknown. This study aimed at highlighting the role of HDL in FH. Methods: HDL-specific phospholipid efflux (HDL-SPE) assay was developed to predict CVD risk. HDL-SPE was examined in FH patients (n=30) and compared with age- and sex-matched non-FH controls (n=60). Results: FH patients had significantly lower HDL-SPE levels (0.90±0.12) than controls (1.12±0.10; p <0.05), despite similar HDL-cholesterol levels in both groups (FH: 57.9±18.7 mg/dl; controls: 57.1±13.8 mg/dl). These differences remained significant after adjusting for confounders. Conclusions: These findings suggest there may be dysfunctionality of HDL in FH. (© 2024 by the Association of Clinical Scientists, Inc.)
Databáze:	MEDLINE
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