Distinctive clinical traits of lupus-related myocarditis: a multicentre retrospective study.

Autor:	Ramirez GA; Università Vita-Salute San Raffaele, Milan, Italy.; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy., Holopainen NEA; Università Vita-Salute San Raffaele, Milan, Italy.; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy., Gerosa M; Department of Clinical Science of Community Health and Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milan, Italy.; Unit of Clinical Rheumatology, ASST Gaetano Pini -CTO, Milan, Italy., De Luca G; Università Vita-Salute San Raffaele, Milan, Italy.; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy., Bellocchi C; Department of Clinical Science of Community Health and Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milan, Italy.; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Policlinico, Milan, Italy., Arroyo-Sánchez D; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy.; Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.; Instituto de Investigación Biomédica Hospital 12 de Octubre, Madrid, Spain., Sala S; Unit of Cardiology, IRCCS Ospedale San Raffaele, Milan, Italy., Peretto G; Unit of Cardiology, IRCCS Ospedale San Raffaele, Milan, Italy., Moroni L; Università Vita-Salute San Raffaele, Milan, Italy.; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy., Mastropaolo F; Università Vita-Salute San Raffaele, Milan, Italy.; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy., Argolini LM; Unit of Clinical Rheumatology, ASST Gaetano Pini -CTO, Milan, Italy., Pizzetti G; Unit of Cardiology, IRCCS Ospedale San Raffaele, Milan, Italy., Palmisano A; Unit of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy., Esposito A; Unit of Radiology, IRCCS Ospedale San Raffaele, Milan, Italy., Cariddi A; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy., Sartorelli S; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy., Campochiaro C; Università Vita-Salute San Raffaele, Milan, Italy.; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy., Beretta L; Department of Clinical Science of Community Health and Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milan, Italy.; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Policlinico, Milan, Italy., Bozzolo EP; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy., Caporali R; Department of Clinical Science of Community Health and Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milan, Italy.; Unit of Clinical Rheumatology, ASST Gaetano Pini -CTO, Milan, Italy., Dagna L; Università Vita-Salute San Raffaele, Milan, Italy.; IRCCS Ospedale San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Milan, Italy.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Jul 24. Date of Electronic Publication: 2024 Jul 24.
DOI:	10.1093/rheumatology/keae376
Abstrakt:	Objectives: Cardiovascular involvement in systemic lupus erythematosus (SLE) is frequent but little is known about possible distinctive traits of SLE-related myocarditis (myoSLE) in comparison to patients with SLE (onlySLE) or myocarditis alone (onlyMyo). Methods: A retrospective analysis was performed comparing patients with myoSLE (n = 25) from three centres with consecutive patients with onlySLE (n = 279) and onlyMyo (n = 88). SLE patients were dichotomised by disease duration ≤1 vs >1 year into recent onlySLE/early myoSLE vs longstanding onlySLE/late myoSLE. Further stratification into disease duration of 1-5, 5-10 and >10 years was also performed. SLE disease activity index 2000 (SLEDAI-2K) was used to estimate disease activity. Myocarditis was diagnosed through biopsy or magnetic resonance. Results: Women were significantly more frequent among myoSLE than among onlyMyo (72% vs 43%; p= 0.013). Compared with onlyMyo, myoSLE patients had a higher frequency of conduction abnormalities (22% vs 5%; p= 0.046) and presented with numerically higher frequencies of left ventricular function compromise (48% vs 30%), along with higher pro-brain natriuretic peptide levels. Inflammation markers were higher in myoSLE compared with onlyMyo and to patients with onlySLE with >10 years of disease duration. SLEDAI-2K was significantly higher in late myoSLE than in longstanding onlySLE. Antiphospholipid syndrome was more frequent in myoSLE than in onlySLE. Multivariate analysis showed an association among myoSLE, anti-beta-2-glycoprotein I antibodies (aB2GPI, p= 0.014) and a higher number of involved British Isles Lupus Assessment Group domains in patient history (p= 0.003). Conclusion: myoSLE has unique clinical traits compared with other forms of myocarditis and is associated with aB2GPI and a more severe SLE course. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology.)
Databáze:	MEDLINE
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