Impact of Systolic Blood Viscosity on Deep White Matter Hyperintensities in Patients With Acute Ischemic Stroke.

Autor: Lee M; Department of Neurology Hallym University Sacred Heart Hospital, Hallym University College of Medicine Anyang Republic of Korea., Park SH; Department of Neurology Soonchunhyang University Seoul Hospital Seoul Republic of Korea., Kim YJ; Department of Neurology, Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Republic of Korea., Bae JS; Department of Neurology, Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Republic of Korea., Lee JH; Department of Neurology, Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Republic of Korea., Lee SH; Department of Neurology Chuncheon Sacred Heart Hospital, Hallym University College of Medicine Chuncheon Republic of Korea., Kim C; Department of Neurology Chuncheon Sacred Heart Hospital, Hallym University College of Medicine Chuncheon Republic of Korea., Lee K; Research Institute, NEUROPHET Inc Seoul Republic of Korea., Kim Y; Department of Neurology, Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Republic of Korea.
Jazyk: angličtina
Zdroj: Journal of the American Heart Association [J Am Heart Assoc] 2024 Aug 06; Vol. 13 (15), pp. e034162. Date of Electronic Publication: 2024 Jul 23.
DOI: 10.1161/JAHA.123.034162
Abstrakt: Background: Elevated blood viscosity (BV), a critical determinant in blood rheology, is a contributing factor in cerebrovascular diseases. The specific influence of BV on small vessel disease burden remains unexplored. This study aims to examine the relationship between BV and regional white matter hyperintensity (WMH) volume in patients with acute ischemic stroke.
Methods and Results: We enrolled a cohort of 302 patients with acute ischemic stroke or transient ischemic attack who were admitted to a hospital within 7 days of symptom onset in this study. We measured whole BV using a scanning capillary-tube viscometer and categorized systolic blood viscosity into 3 groups based on established references. We quantified and normalized WMH volumes using automated localization and segmentation software by NEUROPHET Inc. We performed multivariable logistic regression analysis to assess the correlation between systolic BV and WMH. The mean subject age was 66.7±13.4 years, and 38.7% (n=117) of the participants were female. Among a total of 302 patients, patients with higher deep WMH volume (T3) were typically older and had an atrial fibrillation, strokes of cardioembolic or undetermined cause, elevated levels of C-reactive protein, diastolic blood viscosity and systolic BV. A multivariable adjustment revealed a significant association between high systolic BV and increased deep-WMH volume (odds ratio [OR], 2.636 [95% CI, 1.225-5.673]).
Conclusions: Elevated systolic BV is more likely to be associated with deep WMH volume in patients with acute ischemic stroke or transient ischemic attack. These findings reveal novel therapeutic strategies focusing on blood rheology to enhance cerebral microcirculation in stroke management.
Databáze: MEDLINE
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