Murine glial protrusion transcripts predict localized Drosophila glial mRNAs involved in plasticity.
| Autor: | Lee JY; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Gala DS; Department of Biochemistry, University of Oxford, Oxford, UK., Kiourlappou M; Department of Biochemistry, University of Oxford, Oxford, UK., Olivares-Abril J; Department of Biochemistry, University of Oxford, Oxford, UK., Joha J; Department of Biochemistry, University of Oxford, Oxford, UK., Titlow JS; Department of Biochemistry, University of Oxford, Oxford, UK., Teodoro RO; iNOVA4Health, NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal., Davis I; School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Department of Biochemistry, University of Oxford, Oxford, UK. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of cell biology [J Cell Biol] 2024 Oct 07; Vol. 223 (10). Date of Electronic Publication: 2024 Jul 22. |
| DOI: | 10.1083/jcb.202306152 |
| Abstrakt: | The polarization of cells often involves the transport of specific mRNAs and their localized translation in distal projections. Neurons and glia are both known to contain long cytoplasmic processes, while localized transcripts have only been studied extensively in neurons, not glia, especially in intact nervous systems. Here, we predict 1,740 localized Drosophila glial transcripts by extrapolating from our meta-analysis of seven existing studies characterizing the localized transcriptomes and translatomes of synaptically associated mammalian glia. We demonstrate that the localization of mRNAs in mammalian glial projections strongly predicts the localization of their high-confidence Drosophila homologs in larval motor neuron-associated glial projections and are highly statistically enriched for genes associated with neurological diseases. We further show that some of these localized glial transcripts are specifically required in glia for structural plasticity at the nearby neuromuscular junction synapses. We conclude that peripheral glial mRNA localization is a common and conserved phenomenon and propose that it is likely to be functionally important in disease. (© 2024 Lee et al.) |
| Databáze: | MEDLINE |
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