[A multicenter clinical study on the incidence and influencing factors of cephalosporin-induced anaphylaxis].

Autor:	Yang P; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. tracystrawberry@zju.edu.cn.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou 310003, China. tracystrawberry@zju.edu.cn.; Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Clinical Evaluation and Translational Research, Hangzhou 310003, China. tracystrawberry@zju.edu.cn., Dai D; Department of Pharmacy, the First Affiliated Hospital of Ningbo University, Ningbo 315000, Zhejiang Province, China., Li Q; Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China., Zhan H; Department of Clinical Pharmacy, Jinhua Central Hospital, Jinhua 321000, Zhejiang Province, China., Li X; Department of Clinical Pharmacy, the Second Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, China., Lu X; Department of Clinical Pharmacy, Ningbo Second Hospital, Ningbo 315010, Zhejiang Province, China., He M; Department of Clinical Pharmacy, Department of Clinical Pharmacy, Xiaoshan District First People's Hospital, Hangzhou 311200, China., Chen N; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou 310003, China.; Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Clinical Evaluation and Translational Research, Hangzhou 310003, China., Jiang S; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. j5145@zju.edu.cn.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou 310003, China. j5145@zju.edu.cn.; Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Clinical Evaluation and Translational Research, Hangzhou 310003, China. j5145@zju.edu.cn., Lu X; Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. luxiaoyang@zju.edu.cn.; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Hangzhou 310003, China. luxiaoyang@zju.edu.cn.; Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine for Clinical Evaluation and Translational Research, Hangzhou 310003, China. luxiaoyang@zju.edu.cn.
Jazyk:	čínština
Zdroj:	Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2024 Oct 25; Vol. 53 (5), pp. 615-622.
DOI:	10.3724/zdxbyxb-2024-0100
Abstrakt:	Objectives: To investigate the incidence and influencing factors of allergic reactions to cephalosporins. Methods: A cross-sectional study of 29 medical institutions in Zhejiang Province was conducted from April 2021 to June 2021. The incidence of allergic reactions to cephalosporins was investigated, and the influencing factors of cephalosporin-induced allergic reactions were analyzed by Poisson regression. Results: A total of 56 155 patients were included in this study. The total incidence of allergic reactions to cephalosporin was 1.67‰, the highest incidence of anaphylaxis occurred for ceftizoxime (4.27‰), followed by ceftriaxone (3.49‰) and cefotaxime (2.40‰). There was no significant difference in the incidence of allergic reactions between patients with negative skin tests and those without skin tests (1.75‰ vs . 1.63‰, RR =1.07, 95% CI : 0.70-1.63, P >0.05). Poisson regression showed that body mass index (BMI) <18.5 kg/m 2 ( RR =2.43, 95% CI : 1.23-4.82, P <0.05) and history of β-lactam antibiotics allergy ( RR =33.88, 95% CI : 1.47-781.12, P <0.05) increased cephalosporin-induced anaphylaxis. Compared with cefuroxime, the risk of allergic reactions was increased for ceftriaxone ( RR =3.08, 95% CI : 1.70-5.59, P <0.01), ceftazidime ( RR =1.89, 95% CI : 1.03-3.47, P <0.05), and ceftizoxime ( RR =3.74, 95% CI : 1.64-8.50, P <0.01). Conclusions: Lower BMI and history of β-lactam antibiotics allergy increase the risk of cephalosporin allergic reactions. The routine skin test may not reduce the occurrence of allergic reactions to cephalosporins.
Databáze:	MEDLINE
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