Effect of tablets containing a paraprobiotic strain and the cranberry extract on caries incidence in preschool children: A randomized controlled trial.

Autor:	Olczak-Kowalczyk D; Department of Pediatric Dentistry, Faculty of Dentistry, Medical University of Warsaw, Poland., Turska-Szybka A; Department of Pediatric Dentistry, Faculty of Dentistry, Medical University of Warsaw, Poland., Twetman S; Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Gozdowski D; Department of Experimental Statistics and Bioinformatics, Warsaw University of Life Sciences, Poland., Piekoszewska-Ziętek P; Department of Pediatric Dentistry, Faculty of Dentistry, Medical University of Warsaw, Poland., Góra J; Department of Pediatric Dentistry, Faculty of Dentistry, Medical University of Warsaw, Poland., Wróblewska M; Department of Dental Microbiology, Faculty of Dentistry, Medical University of Warsaw, Poland.
Jazyk:	angličtina
Zdroj:	Dental and medical problems [Dent Med Probl] 2024 Jul 18. Date of Electronic Publication: 2024 Jul 18.
DOI:	10.17219/dmp/171895
Abstrakt:	Background: Preand probiotics may help restore a dysbiotic oral ecosystem. The first years of life provide a window of opportunity to modulate the composition of the oral microbiota and prevent disease. Objectives: The aim of the present study was to investigate the effect of a tablet containing inactivated Ligilactobacillus salivarius CECT 5317 and the cranberry extract on the development of caries in cariesactive preschool children. Material and Methods: The study employed a randomized, placebo-controlled, double-blind design. Preschool children (N = 73) with at least one active carious lesion were enrolled and randomly assigned to the test group or the placebo group. The intervention period was 3 months. Caries was assessed according to the International Caries Detection and Assessment System (ICDAS) II criteria at baseline and after 9 months, and oral hygiene was evaluated with the simplified oral hygiene index (OHI-S). The salivary counts of Streptococcus mutans and Lactobacillus spp. were determined at baseline, and then after 3 and 9 months through the conventional cultivation on TYCSB and MRS agar, respectively. Results: Sixty children completed the trial (a dropout rate of 19%). The baseline caries prevalence was high in both groups (~71%) and there were no major differences between the groups with regard to background variables. The 9-month incidence of initial carious lesions (ICDAS 1+2) was significantly lower in the test group as compared to the placebo group (p < 0.05). The plaque levels, and the salivary counts of S. mutans and Lactobacillus spp. remained unchanged in both groups throughout the study. Conclusions: A daily intake of a tablet containing a paraprobiotic and the cranberry extract reduced the 9-month incidence of initial non-cavitated carious lesions in caries-active preschool children. The present study is one of the first to show the impact of synbiotics on the development of caries in children.
Databáze:	MEDLINE
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